Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis.

Autor: Smirnova N; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, AllergyAtlanta, GA, USA., Lowers J; Division of Palliative Medicine, Department of Family and Preventive Medicine, Emory University, Atlanta, GA, USA., Magee MJ; Rollins School of Public Health, Emory University, Atlanta, GA, USA., Auld SC; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, AllergyAtlanta, GA, USA., Hunt WR; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, AllergyAtlanta, GA, USA., Fitzpatrick A; Department of Pediatrics, Emory University, Randall Rollins Building, #R544, 1516 Clifton Road, NE, Atlanta, GA, 30322, USA., Lama V; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, AllergyAtlanta, GA, USA., Kavalieratos D; Division of Palliative Medicine, Department of Family and Preventive Medicine, Emory University, Atlanta, GA, USA. d.kavalieratos@emory.edu.; Rollins School of Public Health, Emory University, Atlanta, GA, USA. d.kavalieratos@emory.edu.; Department of Pediatrics, Emory University, Randall Rollins Building, #R544, 1516 Clifton Road, NE, Atlanta, GA, 30322, USA. d.kavalieratos@emory.edu.
Jazyk: angličtina
Zdroj: Lung [Lung] 2023 Dec; Vol. 201 (6), pp. 635-639. Date of Electronic Publication: 2023 Nov 16.
DOI: 10.1007/s00408-023-00658-y
Abstrakt: Purpose: People living with cystic fibrosis (CF) experience impaired quality of life, but the extent to which pulmonary function is associated with quality of life in CF remains unclear METHODS: Using baseline data from a trial of specialist palliative care in adults with CF, we examined the association between pulmonary obstruction and quality of life (measured with the Functional Assessment of Chronic Illness Therapy Total Score).
Results: Among 262 participants, median age was 33, and 78% were on modulator therapy. The median quality of life score was higher in those with mild obstruction (135, IQR 110-156) compared to moderate (125, IQR 109-146) and severe obstruction (120, IQR 106-136). In an unadjusted model, we observed a non-significant trend toward lower quality of life with increased obstruction-compared to participants with mild obstruction, those with moderate obstruction had quality of life score 7.46 points lower (95% CI -15.03 to 0.10) and those with severe obstruction had a score 9.98 points lower (95% CI -21.76 to 1.80). However, this association was no longer statistically significant in the adjusted model, which may reflect confounding due to sex, age, BMI, and modulator therapy. Comorbidities (depression and anxiety) and social determinants of health (financial insecurity and education) were also associated with quality of life.
Conclusion: Advancing our understanding of patient-centered markers of quality of life, rather than focusing on pulmonary function alone, may help identify novel interventions to improve quality of life in this patient population.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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