Campomanesia adamantium O Berg. fruit, native to Brazil, can protect against oxidative stress and promote longevity.

Autor: de Araújo LCA; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Leite NR; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., da Rocha PDS; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Baldivia DDS; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Agarrayua DA; Research Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., Ávila DS; Research Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., da Silva DB; Laboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Carollo CA; Laboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil., Campos JF; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Souza KP; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Dos Santos EL; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Nov 16; Vol. 18 (11), pp. e0294316. Date of Electronic Publication: 2023 Nov 16 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0294316
Abstrakt: Campomanesia adamantium O. Berg. is a fruit tree species native to the Brazilian Cerrado biome whose fruits are consumed raw by the population. The present study determined the chemical composition of the C. adamantium fruit pulp (FPCA) and investigated its in vitro antioxidant potential and its biological effects in a Caenorhabditis elegans model. The chemical profile obtained by LC-DAD-MS identified 27 compounds, including phenolic compounds, flavonoids, and organic carboxylic acids, in addition to antioxidant lipophilic pigments and ascorbic acid. The in vitro antioxidant activity was analysed by the radical scavenging method. In vivo, FPCA showed no acute reproductive or locomotor toxicity. It promoted protection against thermal and oxidative stress and increased the lifespan of C. elegans. It also upregulated the antioxidant enzymes superoxide dismutase and glutathione S-transferase and activated the transcription factor DAF-16. These results provide unprecedented in vitro and in vivo evidence for the potential functional use of FPCA in the prevention of oxidative stress and promotion of longevity.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 de Araújo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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