Clinical effectiveness of screening for age-related macular degeneration: A systematic review.

Autor: Gomes DF; Graduate Program in Collective Health, University of Brasilia, Brasília, Federal District, Brazil., Curado DDSP; Department of Management and Incorporation of Health Technologies, Ministry of Health, Brasilia, Federal District, Brazil., Gomes RM; Department of Social Pharmacy, College of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Faculty of Health Sciences, Department of Pharmacy, University of Brasilia, Brasilia, Brazil., Leite BF; Department of Medicine, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil., Ramos MC; Graduate Program in Collective Health, University of Brasilia, Brasília, Federal District, Brazil., Silva END; Graduate Program in Collective Health, University of Brasilia, Brasília, Federal District, Brazil.; Faculty of Ceilandia, University of Brasilia, Brasilia, Federal District, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Nov 16; Vol. 18 (11), pp. e0294398. Date of Electronic Publication: 2023 Nov 16 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0294398
Abstrakt: Introduction: Age-related macular degeneration (AMD) is an eye disease that occurs in patients over 50 years old. Early diagnosis enables timely treatment to stabilize disease progression. However, the fact that the disease is asymptomatic in its early stages can delay treatment until it progresses. As such, screening in specific contexts can be an early detection tool to reduce the clinical and social impact of the disease.
Objective: Assess the effectiveness of screening methods for early detection of AMD in adults aged 50 years or older.
Methods: A systematic review of comparative observational studies on AMD screening methods in those aged 50 years or older, compared with no screening or any other strategy. A literature search was conducted in the MEDLINE (via PubMed), Embase, Cochrane Library and Lilacs database.
Results: A total of 5,290 studies were identified, three of which met the inclusion criteria and were selected for the systematic review. A total of 8,733 individuals (16,780 eyes) were included in the analysis. The screening methods assessed were based on optical coherence tomography (OCT) compared with color fundus photography, and OCT and telemedicine testing compared to a standard eye exam.
Conclusion: The systematized data are limited and only suggest satisfactory performance in early screening of the population at risk of developing AMD. OCT and the telemedicine technique showed promising results in AMD screening. However, methodological problems were identified in the studies selected and the level of evidence was considered low.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Gomes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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