Impact of silver ions and silver nanoparticles on biochemical parameters and antioxidant enzyme modulations in Saccharomyces cerevisiae under co-exposure to static magnetic field: a comparative investigation.

Autor: Kthiri A; Laboratory of Biochemistry and Molecular Biology, Carthage University, Faculty of Sciences of Bizerte, Zarzouna, Bizerte, Tunisia.; Department of Molecular Biology and Genetics, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates., Hamimed S; Molecular and Cellular Biology Laboratory (MCBL), Department of Molecular and Cellular Biology, Faculty of Nature and Life Sciences, University of Jijel, Jijel, Algeria. selma.hamimed@univ-jijel.dz., Tahri W; Laboratory of Biochemistry and Molecular Biology, Carthage University, Faculty of Sciences of Bizerte, Zarzouna, Bizerte, Tunisia., Landoulsi A; Laboratory of Biochemistry and Molecular Biology, Carthage University, Faculty of Sciences of Bizerte, Zarzouna, Bizerte, Tunisia., O'Sullivan S; Department of Molecular Biology and Genetics, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates., Sheehan D; School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.; Department of Chemistry, College of Arts and Sciences, Khalifa University of Science and Technology, PO, Box 127788, Abu Dhabi, United Arab Emirates.
Jazyk: angličtina
Zdroj: International microbiology : the official journal of the Spanish Society for Microbiology [Int Microbiol] 2024 Aug; Vol. 27 (4), pp. 953-966. Date of Electronic Publication: 2023 Nov 16.
DOI: 10.1007/s10123-023-00453-y
Abstrakt: The increase in simultaneous exposure to magnetic fields and other hazardous compounds released from industrial applications poses multiple stress conditions on the ecosystems and public human health. In this work, we investigated the effects of co-exposure to a static magnetic field (SMF) and silver ions (AgNO 3 ) on biochemical parameters and antioxidant enzyme activities in the yeast Saccharomyces cerevisiae. Sub-chronic exposure to AgNO 3 (0.5 mM) for 9 h resulted in a significant decrease in antioxidant enzyme activity, including glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and glutathione transferase (GST). The total glutathione (GSH) level increased in yeast cells exposed to Ag. Additionally, a notable elevation in malondialdehyde (MDA) levels and protein carbonyl content was observed in both the AgNP and AgNO 3 groups compared to the control group. Interestingly, the SMF alleviated the oxidative stress induced by silver nitrate, normalizing antioxidant enzyme activities by reducing cellular ROS formation, MDA levels, and protein carbonylation (PCO) concentrations.
(© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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