Biomarkers of Hepatic Dysfunction and Cardiovascular Risk.

Autor: Lee TB Jr; VCU Health, Department of Internal Medicine, Richmond, VA, USA., Kueh MTW; UCD School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.; Royal College of Surgeons in Ireland & University College Dublin Malaysia Campus, George Town, Malaysia., Jain V; Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA., Razavi AC; Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA., Alebna P; VCU Health Pauley Heart Center, Richmond, VA, USA., Chew NWS; Department of Cardiology, National University Heart Centre, National University Health System, Singapore, Singapore., Mehta A; VCU Health Pauley Heart Center, Richmond, VA, USA. anurag.mehta@vcuhealth.org.; Preventive Cardiology, Internal Medicine, Virginia Commonwealth University School of Medicine, 1200 East Broad Street, PO Box 980036, Richmond, VA, 23298, USA. anurag.mehta@vcuhealth.org.
Jazyk: angličtina
Zdroj: Current cardiology reports [Curr Cardiol Rep] 2023 Dec; Vol. 25 (12), pp. 1783-1795. Date of Electronic Publication: 2023 Nov 16.
DOI: 10.1007/s11886-023-01993-5
Abstrakt: Purpose of Review: The objective of this manuscript is to examine the current literature on non-alcoholic fatty liver disease (NAFLD) biomarkers and their correlation with cardiovascular disease (CVD) outcomes and cardiovascular risk scores.
Recent Findings: There has been a growing appreciation for an independent link between NAFLD and CVD, culminating in a scientific statement by the American Heart Association in 2022. More recently, studies have begun to identify biomarkers of the three NAFLD phases as potent predictors of cardiovascular risk. Despite the body of evidence supporting a connection between hepatic biomarkers and CVD, more research is certainly needed, as some studies find no significant relationship. If this relationship continues to be robust and readily reproducible, NAFLD and its biomarkers may have an exciting role in the future of cardiovascular risk prediction, possibly as risk-enhancing factors or as components of novel cardiovascular risk prediction models.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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