Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam.

Autor:	Silcocks M; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Parkville, Victoria, Australia., Chang X; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Parkville, Victoria, Australia.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore , , Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System , Singapore., Thuong Thuong NT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford , Oxford, United Kingdom., Qin Y; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute , Melbourne, Victoria, Australia.; School of BioSciences, The University of Melbourne , Melbourne, Victoria, Australia., Minh Ha DT; Pham Ngoc Thach Hospital for TB and Lung Disease, District 5 , Ho Chi Minh City, Vietnam., Khac Thai PV; Pham Ngoc Thach Hospital for TB and Lung Disease, District 5 , Ho Chi Minh City, Vietnam., Vijay S; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford , Oxford, United Kingdom.; Theoretical Microbial Ecology, Friedrich Schiller University Jena , Jena, Germany., Anh Thu DD; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam., Ngoc Ha VT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam., Ngoc Nhung H; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam., Huu Lan N; Pham Ngoc Thach Hospital for TB and Lung Disease, District 5 , Ho Chi Minh City, Vietnam., Quynh Nhu NT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam., Edwards D; Department of Infectious Diseases, Central Clinical School, Monash University , Melbourne, Victoria, Australia., Nath A; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute , Melbourne, Victoria, Australia., Pham K; Department of Clinical Pathology, The University of Melbourne , Melbourne, Victoria, Australia., Duc Bang N; Pham Ngoc Thach Hospital for TB and Lung Disease, District 5 , Ho Chi Minh City, Vietnam., Hong Chau TT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam.; Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam., Thwaites G; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5 , Ho Chi Minh City, Vietnam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford , Oxford, United Kingdom., Heemskerk AD; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centre , Amsterdam, Netherlands., Chuen Khor C; Genome Institute of Singapore , Singapore., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore , Singapore., Inouye M; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute , Melbourne, Victoria, Australia.; Department of Public Health and Primary Care, Cambridge Baker Systems Genomics Initiative, University of Cambridge , Cambridge, United Kingdom., Ong RT-H; Saw Swee Hock School of Public Health, National University of Singapore , Singapore., Caws M; Liverpool School of Tropical Medicine , Liverpool, United Kingdom.; Birat Nepal Medical Trust , Kathmandu, Nepal., Holt KE; Department of Infectious Diseases, Central Clinical School, Monash University , Melbourne, Victoria, Australia.; Department of Infection Biology, London School of Hygiene & Tropical Medicine , London, United Kingdom., Dunstan SJ; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Parkville, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	Microbiology spectrum [Microbiol Spectr] 2023 Dec 12; Vol. 11 (6), pp. e0256223. Date of Electronic Publication: 2023 Nov 16.
DOI:	10.1128/spectrum.02562-23
Abstrakt:	Importance: Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that Mtb genetic lineage plays in determining the likelihood of resistance evolution. This study offers insight into these questions by assessing the dynamics of resistance evolution in a high-burden Southeast Asian setting with a diverse lineage composition. It demonstrates that there are clear lineage-specific differences in the dynamics of resistance acquisition and transmission and shows that different lineages evolve resistance via characteristic mutational pathways. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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