Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen.
| Autor: | Ontai-Brenning A; Microbial Sciences Institute, Yale University, West Haven, Connecticut, USA.; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA., Hamchand R; Department of Chemistry, Yale University, New Haven, Connecticut, USA.; Institute of Biomolecular Design & Discovery, Yale University, West Haven, Connecticut, USA., Crawford JM; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Chemistry, Yale University, New Haven, Connecticut, USA.; Institute of Biomolecular Design & Discovery, Yale University, West Haven, Connecticut, USA., Goodman AL; Microbial Sciences Institute, Yale University, West Haven, Connecticut, USA.; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA. |
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| Jazyk: | angličtina |
| Zdroj: | MBio [mBio] 2023 Dec 19; Vol. 14 (6), pp. e0190723. Date of Electronic Publication: 2023 Nov 16. |
| DOI: | 10.1128/mbio.01907-23 |
| Abstrakt: | Importance: Mammals do not eat continuously, instead concentrating their feeding to a restricted portion of the day. This behavior presents the mammalian gut microbiota with a fluctuating environment with consequences for host-microbiome interaction, infection risk, immune response, drug metabolism, and other aspects of health. We demonstrate that in mice, gut microbes elevate levels of an intracellular signaling molecule, (p)ppGpp, during the fasting phase of a time-restricted feeding regimen. Disabling this response in a representative human gut commensal species significantly reduces colonization during this host-fasting phase. This response appears to be general across species and conserved across mammalian gut communities, highlighting a pathway that allows healthy gut microbiomes to maintain stability in an unstable environment. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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