Influence of the new dispersible fixed-dose combination anti-Tuberculosis drug on treatment adherence among children with Tuberculosis in Osun State, Nigeria.

Autor: Chijioke-Akaniro O; National Tuberculosis, Leprosy and Buruli Ulcer Control Programme, Nigeria., Akinyemi PA; National Postgraduate Medical College of Nigeria, Ijanikin Lagos State, Nigeria., Asuke S; Bingham University Karu, Nasarwa state, Nigeria., Anyaike C; National Tuberculosis, Leprosy and Buruli Ulcer Control Programme, Nigeria., Uwaezuoke NA; Department of Paediatrics, University of Nigeria Teaching Hospital Ituku-Ozalla Enugu state, Nigeria., Ochuko U; National Tuberculosis, Leprosy and Buruli Ulcer Control Programme, Nigeria., Ubochioma E; National Tuberculosis, Leprosy and Buruli Ulcer Control Programme, Nigeria., Omoniyi A; WHO Country Office Nigeria., Merle CS; Special Programme for Research & Training In Tropical Diseases (TDR), World Health, Organization, Geneva Switzerland., Daniel S; Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria.
Jazyk: angličtina
Zdroj: International health [Int Health] 2024 Sep 05; Vol. 16 (5), pp. 534-543.
DOI: 10.1093/inthealth/ihad104
Abstrakt: Background: The dispersible fixed-dose combination drug has been recommended as the mainstay of treatment for TB in children. However, more needs to be known about its effect on treatment. This study aimed to assess the effectiveness of the formulation on treatment adherence among children with TB.
Methods: A historical cohort design was used to assess and compare adherences of old loose non-dispersible and new dispersible fixed-dose anti-TB drugs, using a convergent parallel mixed-method approach for data collection. Determinants of treatment adherence were assessed using binary logistic regression.
Results: The proportion of children with good treatment adherence was higher in the new dispersible formulation group (82 [64.6%]) relative to the proportion among the loose non-dispersible formulation group (29 [23.4%]). Reports of forgetfulness, travelling and pill burden were significantly higher among those with poor adherence in the loose non-dispersible formulation group. Significant predictors of treatment adherence were acceptability (adjusted OR [AOR]=4.1, p=0.013, 95% CI 1.342 to 12.756), travelling from treatment areas (AOR=8.9, p=0.002, 95% CI 2.211 to 35.771) and forgetfulness (AOR=74.0, p<0.001, 95% CI 23.319 to 234.725).
Conclusions: The determinants of treatment adherence are multifactorial. In addition to ensuring universal access to the drug, flexible referral in case of travelling and ensuring treatment partners' participation to minimise forgetfulness to take pills, are essential.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
Databáze: MEDLINE
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