Prevalence and Risk Factors of Cytomegalovirus Colitis in Inflammatory Bowel Disease Patients in Riyadh, Saudi Arabia: A Tertiary Center Experience.

Autor:	Alotaibi Y; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., AlLehibi A; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Almtawa A; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Alotaibi N; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Alghamdi A; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Alrajhi S; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., AlQutub A; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., AlEid A; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Alamr A; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Ibrahim BA; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Alahmari M; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Alhamidi H; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Ahmad S; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia., Alshammari F; Department of Internal Medicine, King Fahad Medical City, Riyadh, Saudi Arabia., Almotawa F; Department of Internal Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.; Department of Medicine, University of Bisha, Bisha, Saudi Arabia., Altannir Y; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Alghamdi A; Gastroenterology and Hepatology Department, King Fahad Medical City, Riyadh, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Saudi journal of medicine & medical sciences [Saudi J Med Med Sci] 2023 Oct-Dec; Vol. 11 (4), pp. 305-313. Date of Electronic Publication: 2023 Oct 06.
DOI:	10.4103/sjmms.sjmms_175_23
Abstrakt:	Background: Patients with inflammatory bowel disease (IBD) are at a higher risk of cytomegalovirus (CMV) colitis because of their immunocompromised status. There are no studies from Saudi Arabia regarding the prevalence of CMV colitis in patients with IBD. Objective: To determine the prevalence, characteristics, and risk factors of CMV colitis in patients with IBD in Riyadh, Saudi Arabia. Materials and Methods: This retrospective study included patients with a confirmed diagnosis of IBD (aged 14-75 years) who were followed up at King Fahad Medical City, a referral care center in Riyadh, between January 2016 and December 2021; patients with indeterminate colitis or incomplete medical records were excluded. Results: A total of 341 patients with IBD were included, of which 236 (72.2%) had Crohn's disease (CD) and 105 (27.8%) had ulcerative colitis (UC). Qualitative CMV PCR was done for 192 patients (60 UC and 132 CD patients), of which 14 patients were positive for CMV colitis (7.3%), and all positive CMV colitis cases were among UC patients (23.3%). However, the hematoxylin and eosin (H and E) stain and immunohistochemistry were negative for all patients. Most patients with CMV colitis were on steroids (71.4%), had at least one flare-up (64.3%), and were on biologic treatment (71.4%). Significant predictors of CMV colitis were hemoglobin (OR: 0.7; 95% CI: 0.51-0.96), albumin (OR: 0.88; 95% CI: 0.78-0.98), and C-reactive protein (OR: 1.03; 95% CI: 1.01-1.06) levels. Conclusion: This study found that the prevalence of CMV colitis was 7.3% among patients with IBD, and no case was diagnosed in patients with CD. In addition, as all cases diagnosed using qualitative CMV PCR were negative on H and E stain and immunohistochemistry, there is need for large-scale studies to improve the diagnosis of CMV colitis. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Saudi Journal of Medicine & Medical Sciences.)
Databáze:	MEDLINE
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