Demographics and Clinical Characteristics of Patients with Neurocysticercosis: A Retrospective Study from Dali, China.

Autor:	Zhu HX; Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China., Li YC; Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China., Yang XP; Clinical Medical College, Dali University, Dali, Yunnan, China., Chu YH; Clinical Medical College, Dali University, Dali, Yunnan, China., Guo W; Clinical Medical College, Dali University, Dali, Yunnan, China., Chen RX; Clinical Medical College, Dali University, Dali, Yunnan, China., Guo DD; Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China., Cheng LJ; Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China., Li Y; Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
Jazyk:	angličtina
Zdroj:	Saudi journal of medicine & medical sciences [Saudi J Med Med Sci] 2023 Oct-Dec; Vol. 11 (4), pp. 283-291. Date of Electronic Publication: 2023 Oct 06.
DOI:	10.4103/sjmms.sjmms_298_23
Abstrakt:	Background: Neurocysticercosis (NCC), a predominant parasitic disease that affects the central nervous system and presents with diverse clinical manifestations, is a major contributor to acquired epilepsy worldwide, particularly in low-, middle-, and upper middle-income nations, such as China. In China, the Yunnan Province bears a significant burden of this disease. Objective: To describe the demographic, clinical, and radiological features as well as serum and cerebrospinal fluid antibodies to cysticercus in patients with NCC from Dali, Yunnan Province, China. Materials and Methods: This retrospective study included patients who were diagnosed with NCC at The First Affiliated Hospital of Dali University between January 2018 and May 2023 and were residing in Dali, Yunnan Province, China. Results: A total of 552 patients with NCC were included, of which 33.3% belonged to Bai ethnicity. The clinical presentation of NCC exhibited variability that was influenced by factors such as the number, location, and stage of the parasites. Epilepsy/seizure (49.9%) was the most prevalent symptom, with higher occurrence in the degenerative stage of cysts ( P < 0.001). Compared with other locations, cysticerci located in the brain parenchyma are more likely to lead to seizures/epilepsy (OR = 17.45, 95% CI: 7.96-38.25) and headaches (OR = 3.02, 95% CI: 1.23-7.41). Seizures/epilepsy are more likely in patients with cysts in the vesicular (OR = 2.71, 95% CI: 1.12-6.61) and degenerative (OR = 102.38, 95% CI: 28.36-369.60) stages than those in the calcified stage. Seizures was not dependent on the number of lesions. All NCC patients underwent anthelminthic therapy, with the majority receiving albendazole (79.7%). Conclusion: This study provides valuable clinical insights into NCC patients in Dali and underscores the significance of NCC as a leading preventable cause of epilepsy. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Saudi Journal of Medicine & Medical Sciences.)
Databáze:	MEDLINE
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