Hesperidin reduces serum levels of triglyceride after coronary artery bypass graft surgery.

Autor: Booyani Z; Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran., Aryaeian N; Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran., Omidi N; Cardiac Primary Prevention Research Centre, Cardiovascular Disesae Research Institute Tehran University of Medical Sciences Tehran Iran., Khorasanian AS; Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran., Hoseini AF; Department of Biostatistics, School of Health Iran University of Medical Sciences Tehran Iran., Nejatian M; Department of Cardiac Rehabilitation, Tehran Heart Center Tehran University of Medical Sciences Tehran Iran., Jazayeri S; Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran., Morvaridi M; Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran.
Jazyk: angličtina
Zdroj: Food science & nutrition [Food Sci Nutr] 2023 Aug 23; Vol. 11 (11), pp. 7145-7154. Date of Electronic Publication: 2023 Aug 23 (Print Publication: 2023).
DOI: 10.1002/fsn3.3639
Abstrakt: Hesperidin, as an antioxidant and anti-inflammatory agent, has beneficial effects on cardiovascular diseases. This study aimed to determine the effects of hesperidin supplementation on inflammation, oxidative stress, and lipid profile in depressed coronary artery bypass graft surgery (CABG) patients. Eighty patients after coronary artery bypass graft surgery participated in this clinical trial and were randomly divided into two groups. The intervention group received 200 mg/d pure hesperidin supplement and the second group received placebo for 12 weeks. Both groups continued their usual diet. Serum concentrations of inflammatory and stress oxidative markers (hs-CRP, P-selectin, and ox-LDL) were measured and compared at baseline and the end of the intervention. The changes in serum levels of triglyceride were significantly different between the two groups ( p  < .05). HDL-c significantly increased in groups but the differences between the two groups were not statistically significant ( p  > .05). Hesperidin did not affect FBS, other lipid parameters, hs-CRP, P-selectin, and OX-LDL ( p  > .05). SBP and DBP differences were not statistically significant ( p  > .05). After 12 weeks of intervention, hesperidin reduced serum levels of triglyceride in depressed post-CABG patients.
Competing Interests: The authors have declared that there is no conflict of interest.
(© 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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