Acute-on-chronic liver failure induced by antiviral therapy for chronic hepatitis C: A case report.
| Autor: | Zhong JL; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China., Zhao LW; Department of Hematology, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China., Chen YH; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China., Luo YW; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China. luoyw719@163.com. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of clinical cases [World J Clin Cases] 2023 Oct 26; Vol. 11 (30), pp. 7463-7468. |
| DOI: | 10.12998/wjcc.v11.i30.7463 |
| Abstrakt: | Background: There have been no reports of acute-on-chronic liver failure (ACLF) during treatment of chronic hepatitis C (CHC) with direct-acting antivirals (DAAs). Case Summary: We report a 50-year-old male patient with CHC. The patient sought medical attention from the Department of Infectious Diseases at our hospital due to severe yellowing of the skin and sclera, which developed 3 mo previously and attended two consecutive hospitals without finding the cause of liver damage. It was not until 1 mo ago that he was diagnosed with CHC at our hospital. After discharge, he was treated with DAAs. During treatment, ACLF occurred, and timely measures such as liver protection, enzyme lowering, anti-infective treatment, and suppression of inflammatory storms were implemented to control the condition. Conclusion: DAA drugs significantly improve the cure rate of CHC. However, when patients have factors such as autoimmune attack, coinfection, or unclear hepatitis C virus genotype, close monitoring is required during DAA treatment. Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose. (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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