Controlled swelling of biomaterial devices for improved antifouling polymer coatings.

Autor: Jesmer AH; Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, L8S 4M1, Canada., Marple AST; Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, L8S 4M1, Canada., Wylie RG; Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, L8S 4M1, Canada. wylier@mcmaster.ca.; School of Biomedical Engineering, McMaster University, Hamilton, ON, L8S 4M1, Canada. wylier@mcmaster.ca.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 15; Vol. 13 (1), pp. 19950. Date of Electronic Publication: 2023 Nov 15.
DOI: 10.1038/s41598-023-47192-8
Abstrakt: Nonspecific interactions between cells and implantable elastomers often leads to failure modes for devices such as catheters, cosmetic and reconstructive implants, and sensors. To reduce these interactions, device surfaces can be coated with hydrophilic polymers, where greater polymer density enhances antifouling properties. Although graft-from coating techniques result in higher density polymer films and lower fouling in controlled settings, simpler graft-to methods show similar results on complex implanted devices, despite limited density. To address the need for improved graft-to methods, we developed Graft then shrink (GtS) where elastomeric materials are temporarily swollen during polymer grafting. Herein, we demonstrate a graft-to based method for poly(oligo(ethylene glycol) methyl ether methacrylate) (pOEGMA) on swollen silicone, GtS, that enhances grafted polymer content and fouling resistance. Total grafted polymer content of pOEGMA on toluene swollen silicone increased over ~ 13 × compared to non-swollen controls, dependent on the degree of silicone swelling. Increases in total grafted polymer within the top 200 µm of the material led to bacterial and mammalian cell adhesion reductions of 75% and 91% respectively, compared to Shrink then Graft (StG) antifouling polymer coated controls. GtS allows for the simple 3D coating of swellable elastomers (e.g., silicone medical devices) with improved antifouling pOEGMA coatings.
(© 2023. The Author(s).)
Databáze: MEDLINE
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