Neural responses to acute stress predict chronic stress perception in daily life over 13 months.

Autor: Giglberger M; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany., Peter HL; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany., Henze GI; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.; Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany., Kraus E; Department of Psychology, Computational Modeling in Psychology, Ludwig Maximilian University of Munich, Munich, Germany., Bärtl C; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany., Konzok J; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Kreuzpointner L; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany., Kirsch P; Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Kudielka BM; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany., Wüst S; Department of Psychology, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany. stefan.wuest@ur.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 15; Vol. 13 (1), pp. 19990. Date of Electronic Publication: 2023 Nov 15.
DOI: 10.1038/s41598-023-46631-w
Abstrakt: The importance of amygdala, hippocampus, and medial prefrontal cortex (mPFC) for the integration of neural, endocrine, and affective stress processing was shown in healthy participants and patients with stress-related disorders. The present manuscript which reports on one study-arm of the LawSTRESS project, aimed at investigating the predictive value of acute stress responses in these regions for biopsychological consequences of chronic stress in daily life. The LawSTRESS project examined law students either in preparation for their first state examination (stress group [SG]) or in the mid-phase of their study program (control group [CG]) over 13 months. Ambulatory assessments comprising perceived stress measurements and the cortisol awakening response (CAR) were administered on six sampling points (t1 = - 1 year, t2 = - 3 months, t3 = - 1 week, t4 = exam, t5 =  + 1 week, t6 =  + 1 month). In a subsample of 124 participants (SG: 61; CG: 63), ScanSTRESS was applied at baseline. In the SG but not in the CG, amygdala, hippocampus, and (post-hoc analyzed) right mPFC activation changes during ScanSTRESS were significantly associated with the trajectory of perceived stress but not with the CAR. Consistent with our finding in the total LawSTRESS sample, a significant increase in perceived stress and a blunted CAR over time could be detected in the SG only. Our findings suggest that more pronounced activation decreases of amygdala, hippocampus, and mPFC in response to acute psychosocial stress at baseline were related to a more pronounced increase of stress in daily life over the following year.
(© 2023. The Author(s).)
Databáze: MEDLINE
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