Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in mice.

Autor: Ito A; Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Ohnuki Y; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan., Suita K; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan., Matsuo I; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Ishikawa M; Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Mitsubayashi T; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan., Mototani Y; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan., Kiyomoto K; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Tsunoda M; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Morii A; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Nariyama M; Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, 236-8501, Japan., Hayakawa Y; Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Tomonari H; Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan., Okumura S; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan. okumura-s@tsurumi-u.ac.jp.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 15; Vol. 13 (1), pp. 19927. Date of Electronic Publication: 2023 Nov 15.
DOI: 10.1038/s41598-023-43099-6
Abstrakt: Occlusal disharmony is known to affect not only the oral cavity environment, but also the autonomic nervous system in the heart. Since the renin-angiotensin system (RAS) inhibitor captopril (Cap) is one of the first-line drugs for preventing cardiac remodeling in patients with heart failure, we hypothesized that Cap might prevent cardiac dysfunction induced by occlusal disharmony. Here, to test this idea, we used our bite-opening (BO) mouse model, which was developed by cementing a suitable appliance onto the mandibular incisor. Mice were divided into four groups: (1) Control, (2) BO, (3) Cap, and (4) BO + Cap. After 2 weeks, we evaluated cardiac function by echocardiography and confirmed that cardiac function was significantly decreased in the BO group compared to the control, while Cap ameliorated the dysfunction. Cardiac fibrosis, myocyte apoptosis and oxidative stress-induced myocardial damage in the BO group were significantly increased versus the control, and these increases were suppressed by Cap. Cardiac dysfunction induced by BO was associated with dual phosphorylation on PKCδ (Tyr-311/Thr-505), leading to activation of CaMKII with increased phosphorylation of RyR2 and phospholamban. Our results suggest that the RAS might play an important role in the development of cardiac diseases induced by occlusal anomalies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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