Cutaneous apocrine gland neoplasia in 16 captive African wild dogs (Lycaon pictus).

Autor: Mitchell EP; Department of Paraclinical Sciences and Centre for Veterinary Wildlife Research, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa. Electronic address: emily.mitchell@up.ac.za., Henker MS; Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinaerstr. 13, 80539 Munich, Germany., Lemberger K; Vet Diagnostics, 3 Avenue de la Victoire, 69280 Charbonnières-les-Bains, France., Gohl C; Münchener Tierpark Hellabrunn AG, Tierparkstr. 30, 81543 Munich, Germany., Majzoub-Altweck M; Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinaerstr. 13, 80539 Munich, Germany., Falkenau A; Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinaerstr. 13, 80539 Munich, Germany., Caldwell P; Old Chapel Veterinary Clinic, Totiusdal 0134, South Africa., Chenet B; Parc de Lunaret - Zoo de Montpellier, 50 Avenue Agropolis, 34090 Montpellier, France., Mosca M; University of Lyon, VetAgro Sup, UP Interactions Cellules Environnement, 1 Avenue Bourgelat, 69280 Marcy l'Etoile, France., Pin D; University of Lyon, VetAgro Sup, UP Interactions Cellules Environnement, 1 Avenue Bourgelat, 69280 Marcy l'Etoile, France., Denk D; Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinaerstr. 13, 80539 Munich, Germany.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2023 Nov; Vol. 207, pp. 59-65. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1016/j.jcpa.2023.10.005
Abstrakt: This retrospective study documents the occurrence of single and multiple cutaneous apocrine gland tumours (CATs) on the dorsal midline of 16 captive African wild dogs (AWDs, Lycaon pictus) derived from 161 submissions to diagnostic laboratories in South Africa, France and Germany between 1997 and 2022. Animals included in the study came from zoological institutions in South Africa (n = 2), France (n = 5) and Germany (n = 1) and ranged from 5 to 14 years of age. Fifteen affected animals were female (94%) and one was male. CATs presented as raised, hairless, multilobular, grey firm masses, consistently located along the dorsal midline. Apart from a single cutaneous apocrine adenoma and a cystadenoma occurring concurrently with two non-cystic adenocarcinomas, neoplasms were consistent with malignant cutaneous apocrine adenocarcinomas with lymphatic spread and visceral metastases. Advanced age and female sex were identified as risk factors. A genetic component or association with the increasing use of GnRH agonist contraceptives was suspected but could not be established. This study highlights the need for close clinical monitoring of AWDs over the age of 5 years for the development of CATs along the dorsal midline and supports early surgical intervention. More research is needed to determine the role of inbreeding, endocrine changes and husbandry factors that may play a role in the development of CATs on the dorsal midline of AWDs.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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