Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents.

Autor: El-Nashar HAS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Taleb M; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University-Gaza, Gaza, Palestine., El-Shazly M; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., Zhao C; College of Marine Sciences, Fujian Agricultural and Forestry University, Fuzhou, China.; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, China., Farag MA; Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2024 Feb; Vol. 38 (2), pp. 662-693. Date of Electronic Publication: 2023 Nov 15.
DOI: 10.1002/ptr.8067
Abstrakt: Diabetes mellitus is a globally metabolic endocrine syndrome marked by a deficiency of insulin secretion (type-1 DM) or glucose intolerance arising from insulin response impairment (type-2 DM) leading to abnormal glucose metabolism. With an increasing interest in natural dietary components for diabetes management, the identification of novel agents witnessed major discoveries. Plant-derived mucilage, pectin, and inulin are important non-starch polysaccharides that exhibit effective antidiabetic properties often termed soluble dietary fiber (SDF). SDF affects sugar metabolism through multiple mechanisms affecting glucose absorption and diffusion, modulation of carbohydrate metabolizing enzymes (α-amylase and α-glucosidase), ameliorating β-pancreatic cell dysfunction, and improving insulin release or sensitivity. Certain SDFs inhibit dipeptidyl peptidase-4 and influence the expression levels of genes related to glucose metabolism. This review is designed to discuss holistically and critically the antidiabetic effects of major SDF and their underlying mechanisms of action. This review should aid drug discovery approaches in developing novel natural antidiabetic drugs from SDF.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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