Anaerobic growth and drug susceptibility of versatile fungal pathogen Scedosporium apiospermum .
Autor: | Yadav KK; National Centre for Microbial Resource (NCMR), National Centre for Cell Science (NCCS), Pune, Maharashtra 411007, India.; Symbiosis Centre for Waste Resource Management (SCWRM), Symbiosis International, (Deemed University), Lavale, Pune 412115, India., Nimonkar Y; National Centre for Microbial Resource (NCMR), National Centre for Cell Science (NCCS), Pune, Maharashtra 411007, India., Green SJ; Department of Internal Medicine, Division of Infectious Diseases, Rush University Medical Center, Chicago, IL 60607, USA., Dewala S; National Centre for Microbial Resource (NCMR), National Centre for Cell Science (NCCS), Pune, Maharashtra 411007, India., Dhanorkar MN; Symbiosis Centre for Waste Resource Management (SCWRM), Symbiosis International, (Deemed University), Lavale, Pune 412115, India., Sharma R; Department of Life Science and Biological Science, IES University, Bhopal, Madhya Pradesh 462 044, India., Rale VR; Symbiosis Centre for Research and Innovation (SCRI), Symbiosis International, (Deemed University), Lavale, Pune 412115, India., Prakash O; National Centre for Microbial Resource (NCMR), National Centre for Cell Science (NCCS), Pune, Maharashtra 411007, India.; Symbiosis Centre for Climate Change and Sustainability (SCCCS), Symbiosis International, (Deemed University), Lavale, Pune 412115, India. |
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Jazyk: | angličtina |
Zdroj: | IScience [iScience] 2023 Oct 24; Vol. 26 (11), pp. 108304. Date of Electronic Publication: 2023 Oct 24 (Print Publication: 2023). |
DOI: | 10.1016/j.isci.2023.108304 |
Abstrakt: | Although severe cases of invasive mycoses of different hypoxic and anoxic body parts have been reported, growth and drug susceptibility of fungal pathogens under anaerobic conditions remains understudied. The current study evaluated anaerobic growth potential and drug susceptibility of environmental Scedosporium apiospermum isolates under aerobic and anaerobic conditions. All tested strains showed equivalent growth and higher sensitivity to tested antifungal drugs under anaerobic conditions with lower minimum inhibitory concentration (MIC) as compared to aerobic conditions. Antifungal azoles were effective against isolates under both aerobic and anaerobic conditions. Most strains were resistant to antifungal echinocandins and polyenes under aerobic conditions but exhibited sensitivity under anaerobic conditions. This study provides evidence that resistance of S. apiospermum to antifungal drugs varies with oxygen concentration and availability and suggests re-evaluating clinical breakpoints for antifungal compounds to treat invasive fungal infections more effectively. Competing Interests: The authors declare no competing interests. (© 2023.) |
Databáze: | MEDLINE |
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