Seroprevalence of SARS-CoV-2 antibodies and associated risk factors during the second wave of infection in a university community in Cameroon.

Autor: Essomba RG; National Public Health Laboratory (NPHL) Ministry of Public Health Yaoundé Cameroon.; Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé I Yaoundé Cameroon.; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon.; National Public Health Emergency Operations Coordination Centre (NPHEOCC) Ministry of Public Health Yaoundé Cameroon., Bayibeki AN; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Lissom A; Department of Zoology, Faculty of Sciences University of Bamenda (UBa) Bamenda Cameroon., Ateba PT; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Seni N; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Fouda CAN; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Mbitock SBD; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Ebonda ND; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Afana SD; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Akame S; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Tembu AA; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Ngamaleu MR; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Bimai BCB; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Kabo O; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Nguwoh PS; National Public Health Laboratory (NPHL) Ministry of Public Health Yaoundé Cameroon., Ngounouh CT; Higher Institute of Sciences and Techniques Applied to Health, Faculty of Medicine and Pharmaceutical Sciences University of Douala Yaoundé Cameroon., Meka MCJ; National Public Health Laboratory (NPHL) Ministry of Public Health Yaoundé Cameroon., Kengne M; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Likeng JN; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Kimessoukie EO; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Nkoum BA; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Assoumou MCO; National Public Health Laboratory (NPHL) Ministry of Public Health Yaoundé Cameroon.; Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé I Yaoundé Cameroon.; Higher Institute of Sciences and Techniques Applied to Health, Faculty of Medicine and Pharmaceutical Sciences University of Douala Yaoundé Cameroon., Fokam J; Higher Institute of Sciences and Techniques Applied to Health, Faculty of Medicine and Pharmaceutical Sciences University of Douala Yaoundé Cameroon.; Laboratory of Virology Chantal BIYA International Reference Center for Research HIV/AIDS Prevention and Management (CIRCB) Yaoundé Cameroon.; Faculty of Health Sciences University of Buea (UB) Buea Cameroon., Yap Boum II; Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé I Yaoundé Cameroon.; Pasteur Institute Bangui (IPB) Bangui Central African Republic.; Higher Institute of Sciences and Techniques Applied to Health, Faculty of Medicine and Pharmaceutical Sciences University of Douala Yaoundé Cameroon., Ambomo MS; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon., Chadou MJP; School of Health Sciences Catholic University of Central Africa (ESS-UCAC) Yaoundé Cameroon.
Jazyk: angličtina
Zdroj: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2023 Nov 12; Vol. 17 (11), pp. e13222. Date of Electronic Publication: 2023 Nov 12 (Print Publication: 2023).
DOI: 10.1111/irv.13222
Abstrakt: Background: The COVID-19 pandemic has caused a public health emergency in all sectors of society, including universities and other academic institutions in Cameroon. However, little is known concerning the real prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among student communities during the second wave of infection in Cameroon. This study aimed to estimate SARS-CoV-2 antibodies seroprevalence among participants in a university community in Cameroon.
Methodology: A cross-sectional study was conducted from March to April 2021 in 547 students aged ≥18 years during a mass diagnostic campaign at the School of Health Sciences of the Catholic University of Central Africa (ESS/UCAC). The anti-SARS-CoV-2 antibody screening was done using the Panbio™ COVID-19 IgG/IgM Rapid Diagnostic Test.
Results: The overall seroprevalence of SARS-CoV-2 antibodies was 27%, of which 89.9% ( n =  133) was IgG, 6.7% ( n =  10) IgM and 3.4% ( n =  5) IgG/IgM positive. The undergraduate students represented 79% (432/547) of the total population and were highly positive with anti-SARS-CoV-2 antibodies 30% (130/432) as compared with postgraduate students 20% (23/115). The total antibody seropositivity was higher in males (34.4%) than females (24.9%). Several factors were associated with an increased risk of SARS-CoV-2 seroprevalence including the male gender (OR: 1.61 [95% confidence interval, CI 1.0-2.4]), specialization to medical laboratory (OR: 2.8 [95% CI 1.1-7.1]) and nursing sciences (OR: 2.6 [95% CI 1.1-6.2]).
Conclusion: Our findings point to extensive and underreported circulation of SARS-CoV-2 in a university community during the second wave of infection in Cameroon, which likely resulted in artificially low case counts.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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