Decarboxylative halogenation of indoles by vanadium haloperoxidases.

Autor: Harstad LJ; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA., Wells CE; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA., Lee HJ; Department of Chemistry, Emory University, Atlanta, GA 30322, USA. kbiegas@emory.edu.; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA., Ramos LPT; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA., Sharma M; Department of Chemistry, Emory University, Atlanta, GA 30322, USA. kbiegas@emory.edu.; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA., Pascoe CA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA., Biegasiewicz KF; Department of Chemistry, Emory University, Atlanta, GA 30322, USA. kbiegas@emory.edu.; School of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Nov 30; Vol. 59 (96), pp. 14289-14292. Date of Electronic Publication: 2023 Nov 30.
DOI: 10.1039/d3cc04053d
Abstrakt: Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases are capable of producing 3-haloindoles through decarboxylative halogenation of 3-carboxyindoles. This biocatalytic method is applicable to decarboxylative chlorination, bromination, and iodination in moderate to high yields and with excellent chemoselectivity.
Databáze: MEDLINE