Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I-II inhibition properties.

Autor: Öztürk C; Department of Chemistry, Faculty of Science, Atatürk University, Erzurum, Turkey., Kalay E; Department of Material and Material Processing Technologies, Kars Vocational School, Kafkas University, Kars, Turkey., Gerni S; Department of Chemistry, Faculty of Science, Atatürk University, Erzurum, Turkey., Balci N; Siran Dursun Keles Vocational School of Health Services, Gümüshane University, Gümüshane, Turkey., Tokali FS; Department of Material and Material Processing Technologies, Kars Vocational School, Kafkas University, Kars, Turkey., Aslan ON; East Anatolian High Technology Application and Research Center, Atatürk University, Erzurum, Turkey., Polat E; Department of Chemistry, Faculty of Science, Atatürk University, Erzurum, Turkey.
Jazyk: angličtina
Zdroj: Biotechnology and applied biochemistry [Biotechnol Appl Biochem] 2024 Feb; Vol. 71 (1), pp. 223-231. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1002/bab.2534
Abstrakt: The secondary sulfonamide derivatives containing benzothiazole scaffold (1-10) were synthesized to determine their inhibition properties on two physiologically essential human carbonic anhydrases isoforms (hCAs, EC, 4.2.1.1), hCA I, and hCA II. The inhibitory effects of the compounds on hCA I and hCA II isoenzymes were investigated by comparing their IC 50 and K i values. The K i values of compounds (1-10) against hCA I and hCA II are in the range of 0.052 ± 0.022-0.971 ± 0.280 and 0.025 ± 0.010-0.682 ± 0.335, respectively. Some of these inhibited the enzyme more effectively than the standard drug, acetazolamide. In particular, compounds 5 and 4 were found to be most effective on hCA I and hCA II.
(© 2023 International Union of Biochemistry and Molecular Biology, Inc.)
Databáze: MEDLINE
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