Highly Efficient Oral Iguratimod/Polyvinyl Alcohol Nanodrugs Fabricated by High-Gravity Nanoprecipitation Technique for Treatment of Rheumatoid Arthritis.

Autor: Tao C; College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China., Li F; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China., Ma Z; Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, 100191, P. R. China., Li X; College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China., Zhang Y; College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China., Le Y; College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China., Wang J; College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China., Zhao J; Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, 100191, P. R. China., Liu C; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, P. R. China., Zhang J; College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Mar; Vol. 20 (13), pp. e2304150. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1002/smll.202304150
Abstrakt: Rheumatoid arthritis (RA), a systemic autoimmune disease, poses a significant human health threat. Iguratimod (IGUR), a novel disease-modifying antirheumatic drug (DMARD), has attracted great attention for RA treatment. Due to IGUR's hydrophobic nature, there's a pressing need for effective pharmaceutical formulations to enhance bioavailability and therapeutic efficacy. The high-gravity nanoprecipitation technique (HGNPT) emerges as a promising approach for formulating poorly water-soluble drugs. In this study, IGUR nanodrugs (NanoIGUR) are synthesized using HGNPT, with a focus on optimizing various operational parameters. The outcomes revealed that HGNPT enabled the continuous production of NanoIGUR with smaller sizes (ranging from 300 to 1000 nm), more uniform shapes, and reduced crystallinity. In vitro drug release tests demonstrated improved dissolution rates with decreasing particle size and crystallinity. Notably, in vitro and in vivo investigations showcased NanoIGUR's efficacy in inhibiting synovial fibroblast proliferation, migration, and invasion, as well as reducing inflammation in collagen-induced arthritis. This study introduces a promising strategy to enhance and broaden the application of poorly water-soluble drugs.
(© 2023 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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