Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.

Autor:	Kerestes R; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Laansma MA; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Owens-Walton C; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA., Perry A; Monash Bioinformatics Platform, Monash University, Melbourne, Victoria, Australia., van Heese EM; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Al-Bachari S; Faculty of Health and Medicine, The University of Lancaster, Lancaster, United Kingdom., Anderson TJ; New Zealand Brain Research Institute, Christchurch, New Zealand.; Neurology Department, Te Whatu Ora - Health New Zealand Waitaha Canterbury, Christchurch, New Zealand., Assogna F; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Aventurato ÍK; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., van Balkom TD; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Department Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Berendse HW; Department Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van den Berg KRE; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands., Betts R; School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Manchester, United Kingdom., Brioschi R; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil., Carr J; Division of Neurology, Tygerberg Hospital and Stellenbosch University, Cape Town, South Africa., Cendes F; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Clark LR; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Dalrymple-Alford JC; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand.; School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand., Dirkx MF; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., Druzgal J; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA., Durrant H; School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Manchester, United Kingdom., Emsley HCA; Lancaster Medical School, Lancaster University, Lancaster, United Kingdom.; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Garraux G; GIGA-CRC in vivo imaging, University of Liège, Liège, Belgium.; MoVeRe group, Department of Neurology, CHU de Liège, Belgium., Haroon HA; Division of Psychology, Communication and Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Helmich RC; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands., van den Heuvel OA; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Department Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., João RB; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Johansson ME; Department of Neurology and Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., Khachatryan SG; Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia.; Centers for Sleep and Movement Disorders, Somnus Neurology Clinic, Yerevan, Armenia., Lochner C; Department of Psychiatry, SA MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa., McMillan CT; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Melzer TR; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand.; School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand., Mosley PE; Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; The Australian eHealth Research Centre, CSIRO Health and Biosecurity, Brisbane, Queensland, Australia., Newman B; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA., Opriessnig P; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria., Parkes LM; Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance and University of Manchester, Manchester, United Kingdom., Pellicano C; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Piras F; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Pitcher TL; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand., Poston KL; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA., Rango M; Excellence Center for Advanced MR Techniques and Parkinson's Disease Center, Neurology unit, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital, University of Milan, Milan, Italy.; Department of Neurosciences, Neurology Unit, Fondazione Ca' Granda, IRCCS, Ospedale Policlinico, University of Milan, Milano, Italy., Roos A; Department of Psychiatry and Neuroscience Institute, SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa., Rummel C; Support Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Schmidt R; Department of Neurology, Medical University of Graz, Graz, Austria., Schwingenschuh P; Department of Neurology, Medical University of Graz, Graz, Austria., Silva LS; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Smith V; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA., Squarcina L; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Stein DJ; Department of Psychiatry and Neuroscience Institute, SA MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa., Tavadyan Z; Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia.; Centers for Sleep and Movement Disorders, Somnus Neurology Clinic, Yerevan, Armenia., Tsai CC; Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan., Vecchio D; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Vriend C; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, The Netherlands., Wang JJ; Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan.; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan City, Taiwan.; Department of Diagnostic Radiology, Chang Gung Memorial Hospital Keelung Branch, Keelung City, Keelung, Taiwan.; Department of Chemical Engineering, Ming-Chi University of Technology, New Taipei City, Taiwan., Wiest R; Support Center for Advanced Neuroimaging, (SCAN) University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Yasuda CL; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Young CB; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA., van der Werf YD; Department Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Harding IH; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2023 Dec; Vol. 38 (12), pp. 2269-2281. Date of Electronic Publication: 2023 Nov 14.
DOI:	10.1002/mds.29611
Abstrakt:	Background: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated. Objective: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group. Methods: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated. Results: Overall, people with PD had a regionally smaller posterior lobe (d max  = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (d max  = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (d max  = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17). Conclusions: We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. (© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
Databáze:	MEDLINE
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