Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation.

Autor: Vis A; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers location University of Amsterdam, Amsterdam, The Netherlands., de Kort BJ; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands., Szymczyk W; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands., van Rijswijk JW; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands., Dekker S; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands., Driessen R; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands., Wijkstra N; Department of Cardiology, Amsterdam University Medical Centers location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Gründeman PF; Department of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands., Niessen HWM; Department of Pathology, Amsterdam University Medical Centers location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Janssen HM; SyMO-Chem BV, Eindhoven, The Netherlands., Söntjens SHM; SyMO-Chem BV, Eindhoven, The Netherlands., Dankers PYW; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands., Smits AIPM; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands., Bouten CVC; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. c.v.c.bouten@tue.nl.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands. c.v.c.bouten@tue.nl., Kluin J; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers location University of Amsterdam, Amsterdam, The Netherlands. j.kluin@erasmusmc.nl.; Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands. j.kluin@erasmusmc.nl.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2023 Nov 14; Vol. 6 (1), pp. 1166. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1038/s42003-023-05533-3
Abstrakt: Pliable microfibrous, bioresorbable elastomeric heart valve prostheses are investigated in search of sustainable heart valve replacement. These cell-free implants recruit cells and trigger tissue formation on the valves in situ. Our aim is to investigate the behaviour of these heart valve prostheses when exposed to the high-pressure circulation. We conducted a 12-month follow-up study in sheep to evaluate the in vivo functionality and neo-tissue formation of these valves in the aortic position. All valves remained free from endocarditis, thrombotic complications and macroscopic calcifications. Cell colonisation in the leaflets was mainly restricted to the hinge area, while resorption of synthetic fibers was limited. Most valves were pliable and structurally intact (10/15), however, other valves (5/15) showed cusp thickening, retraction or holes in the leaflets. Further research is needed to assess whether in-situ heart valve tissue engineering in the aortic position is possible or whether non-resorbable synthetic pliable prostheses are preferred.
(© 2023. The Author(s).)
Databáze: MEDLINE
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