Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review.

Autor: Kibirige D; Department of Medicine, Uganda Martyrs' Hospital Lubaga, Kampala, Uganda. kibirigedavis@gmail.com.; Clinical Research Unit, Tuberculosis and Comorbidities Consortium, Kampala, Uganda. kibirigedavis@gmail.com., Andia-Biraro I; Clinical Research Unit, Tuberculosis and Comorbidities Consortium, Kampala, Uganda.; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda., Kyazze AP; Clinical Research Unit, Tuberculosis and Comorbidities Consortium, Kampala, Uganda.; Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda., Olum R; Department of Medicine, St. Francis Hospital Nsambya, Kampala, Uganda., Bongomin F; Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda., Nakavuma RM; Clinical Research Unit, Tuberculosis and Comorbidities Consortium, Kampala, Uganda., Ssekamatte P; Clinical Research Unit, Tuberculosis and Comorbidities Consortium, Kampala, Uganda., Emoru R; Clinical Research Unit, Tuberculosis and Comorbidities Consortium, Kampala, Uganda., Nalubega G; Clinical Research Unit, Tuberculosis and Comorbidities Consortium, Kampala, Uganda., Chamba N; Department of Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.; Department of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania., Kilonzo K; Department of Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.; Department of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania., Laizer SN; Department of Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.; Department of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania., Mrema LE; National Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, Tanzania., Olomi W; National Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, Tanzania., Minja LT; National Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, Tanzania., Ntinginya NE; National Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, Tanzania., Sabi I; National Institute for Medical Research-Mbeya Medical Research Centre, Mbeya, Tanzania., Hill PC; Centre for International Health, Otago University, Dunedin, New Zealand., Te Brake L; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., van Crevel R; Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Sharples K; Centre for International Health, Otago University, Dunedin, New Zealand., Critchley J; Population Health Research Institute, St. George's University of London, London, UK.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 14; Vol. 13 (1), pp. 19894. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1038/s41598-023-47285-4
Abstrakt: Diabetes mellitus (DM) increases the risk of developing tuberculosis infection (TBI). However, the evidence on the burden and phenotypic characteristics of TBI in African patients with DM is limited. This study aimed to determine the prevalence and characterisation of TBI in native African patients living with DM. We searched PubMed, EMBASE, and African Journals Online for original studies reporting information on the prevalence and characteristics of TBI in adult Africans with DM. A forest plot was used to describe the pooled prevalence estimate of TBI and the corresponding 95% confidence intervals (CI). Six studies conducted in four African countries involving 721 participants with DM were included in this systematic review. The pooled prevalence estimate of TBI was 40% (95% CI 20-60%, I 2  = 98.52%, p < 0.001). Age ≥ 40 years and glycated haemoglobin levels independently predicted TBI positivity in patients with DM in three studies. Africans with DM have a high prevalence of TBI, especially those who are older or with poorly controlled diabetes. This justifies the need for studies to explore how to screen and manage TBI to avert the progression to active TB disease.
(© 2023. The Author(s).)
Databáze: MEDLINE
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