Circulating serotonin and dopamine concentrations in osteoarthritis patients: a pilot study on the effect of pelotherapy.

Autor: Gálvez I; Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006, Badajoz, Spain.; Departamento de Enfermería, Facultad de Medicina y Ciencias de la Salud, Universidad de Extremadura, 06006, Badajoz, Spain., Hinchado MD; Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006, Badajoz, Spain. mhinsan@unex.es.; Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, 06071, Badajoz, Spain. mhinsan@unex.es., Otero E; Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006, Badajoz, Spain.; Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, 06071, Badajoz, Spain., Navarro MC; Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006, Badajoz, Spain.; Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, 06071, Badajoz, Spain., Ortega-Collazos E; Servicio de Medicina Interna, Hospital San Pedro de Alcántara, 10003, Cáceres, Spain., Martín-Cordero L; Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006, Badajoz, Spain.; Departamento de Enfermería, Centro Universitario de Plasencia, Universidad de Extremadura, 10600, Plasencia, Spain., Torres-Piles ST; Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006, Badajoz, Spain. storres@unex.es.; Departamento de Terapéutica Médico-Quirúrgica, Facultad de Medicina y Ciencias de la Salud, Universidad de Extremadura, 06006, Badajoz, Spain. storres@unex.es., Ortega E; Immunophysiology Research Group, Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 06006, Badajoz, Spain. orincon@unex.es.; Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, 06071, Badajoz, Spain. orincon@unex.es.
Jazyk: angličtina
Zdroj: International journal of biometeorology [Int J Biometeorol] 2024 Jan; Vol. 68 (1), pp. 69-77. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1007/s00484-023-02571-8
Abstrakt: Balneotherapy has demonstrated clinical efficacy in the management of pathologies involving low-grade inflammation and stress. In rheumatic conditions such as osteoarthritis (OA), this therapy presents anti-inflammatory properties and potential to improve psychological well-being. Although the neurohormones serotonin and dopamine are known to be involved in these processes, surprisingly they have not been studied in this context. The objective was to evaluate the effect of a cycle of balneotherapy with peloids (pelotherapy) on circulating serotonin and dopamine concentrations in a group of aged individuals with OA, after comparing their basal state to that of an age-matched control group. In our pilot study, a pelotherapy program (10 days) was carried out in a group of 16 elderly patients with OA, evaluating its effects on circulating serotonin and dopamine concentrations (measured by ELISA). Individuals with OA showed higher levels of serotonin and lower dopamine levels, in line with the inflammatory roles of these mediators. After pelotherapy, serotonin concentrations significantly decreased, potentially contributing to the previously reported anti-inflammatory effects of balneotherapy.
(© 2023. The Author(s).)
Databáze: MEDLINE
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