Metabolomic Signatures of Exposure to Nitrate and Trihalomethanes in Drinking Water and Colorectal Cancer Risk in a Spanish Multicentric Study (MCC-Spain).

Autor:	Alcolea JA; ISGlobal, c/Dr. Aiguader 88, Barcelona 08003, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Universitat Pompeu Fabra (UPF), c/Doctor Aiguader 88, Barcelona 08003, Spain., Donat-Vargas C; ISGlobal, c/Dr. Aiguader 88, Barcelona 08003, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Universitat Pompeu Fabra (UPF), c/Doctor Aiguader 88, Barcelona 08003, Spain.; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden., Chatziioannou AC; International Agency for Research on Cancer, 25 avenue Tony Garnier, CS 90627 69366, Lyon, France., Keski-Rahkonen P; International Agency for Research on Cancer, 25 avenue Tony Garnier, CS 90627 69366, Lyon, France., Robinot N; International Agency for Research on Cancer, 25 avenue Tony Garnier, CS 90627 69366, Lyon, France., Molina AJ; Research Group in Gene - Environment and Health Interactions (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de León, Campus Universitario de Vegazana, León 24071, Spain.; Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de León, Campus Universitario de Vegazana, León 24071, Spain., Amiano P; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa; BioGipuzkoa (BioDonostia) Health Research Institute, San Sebastián 20013, Spain., Gómez-Acebo I; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Universidad de Cantabria-IDIVAL, Avenida Cardenal Herrera Oria S/N, Santander 39011, Spain., Castaño-Vinyals G; ISGlobal, c/Dr. Aiguader 88, Barcelona 08003, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Universitat Pompeu Fabra (UPF), c/Doctor Aiguader 88, Barcelona 08003, Spain.; IMIM (Hospital del Mar Medical Research Institute), c/Doctor Aiguader 88, Barcelona 08003, Spain., Maitre L; ISGlobal, c/Dr. Aiguader 88, Barcelona 08003, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Universitat Pompeu Fabra (UPF), c/Doctor Aiguader 88, Barcelona 08003, Spain., Chadeau-Hyam M; MRC Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom., Dagnino S; MRC Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom.; Transporters in Imaging and Radiotherapy in Oncology (TIRO), School of Medicine, Direction de la Recherche Fondamentale (DRF), Institut des Sciences du Vivant Frédéric Joliot, Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA), Université Côte d'Azur (UCA), 28 Avenue de Valombrose, Nice 06107, France., Cheng SL; MRC Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom., Scalbert A; International Agency for Research on Cancer, 25 avenue Tony Garnier, CS 90627 69366, Lyon, France., Vineis P; MRC Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom., Kogevinas M; ISGlobal, c/Dr. Aiguader 88, Barcelona 08003, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Universitat Pompeu Fabra (UPF), c/Doctor Aiguader 88, Barcelona 08003, Spain.; IMIM (Hospital del Mar Medical Research Institute), c/Doctor Aiguader 88, Barcelona 08003, Spain., Villanueva CM; ISGlobal, c/Dr. Aiguader 88, Barcelona 08003, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, Madrid 28029, Spain.; Universitat Pompeu Fabra (UPF), c/Doctor Aiguader 88, Barcelona 08003, Spain.; IMIM (Hospital del Mar Medical Research Institute), c/Doctor Aiguader 88, Barcelona 08003, Spain.
Jazyk:	angličtina
Zdroj:	Environmental science & technology [Environ Sci Technol] 2023 Dec 05; Vol. 57 (48), pp. 19316-19329. Date of Electronic Publication: 2023 Nov 14.
DOI:	10.1021/acs.est.3c05814
Abstrakt:	We investigated the metabolomic profile associated with exposure to trihalomethanes (THMs) and nitrate in drinking water and with colorectal cancer risk in 296 cases and 295 controls from the Multi Case-Control Spain project. Untargeted metabolomic analysis was conducted in blood samples using ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. A variety of univariate and multivariate association analyses were conducted after data quality control, normalization, and imputation. Linear regression and partial least-squares analyses were conducted for chloroform, brominated THMs, total THMs, and nitrate among controls and for case-control status, together with a N-integration model discriminating colorectal cancer cases from controls through interrogation of correlations between the exposure variables and the metabolomic features. Results revealed a total of 568 metabolomic features associated with at least one water contaminant or colorectal cancer. Annotated metabolites and pathway analysis suggest a number of pathways as potentially involved in the link between exposure to these water contaminants and colorectal cancer, including nicotinamide, cytochrome P-450, and tyrosine metabolism. These findings provide insights into the underlying biological mechanisms and potential biomarkers associated with water contaminant exposure and colorectal cancer risk. Further research in this area is needed to better understand the causal relationship and the public health implications.
Databáze:	MEDLINE
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