| Autor: |
Ganie MA; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.; Natural Product & Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Jammu-180001, India., Fayaz F; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.; Natural Product & Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Jammu-180001, India., Bhat MU; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.; Natural Product & Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Jammu-180001, India., Rizvi MA; Department of Chemistry, University of Kashmir, Srinagar-190006, India., Raheem S; Department of Chemistry, University of Kashmir, Srinagar-190006, India., Shah BA; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.; Natural Product & Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Jammu-180001, India. |
| Abstrakt: |
A mild electron donor-acceptor complex-mediated approach for the synthesis of N -acyl- N,O -hemiacetals has been reported. The key feature of this protocol is that it allows for direct access to electrophilic N -acylimines at room temperature without prefunctionalization of the hydroxyl group. The in situ generated N -acylimine can react with different nucleophiles, viz., alcohols, thiols, and nitriles, to afford a diverse range of scaffolds such as N,O -, N,S -, and N,N -acetals. |
