Neuromuscular Ultrasound Findings of Myokymia in a Young Woman With Generalized Anti-LGI-1 and Anti-Caspr2 Antibodies Negative Isaac Syndrome.
| Autor: | Prado MB Jr; Department of Physiology, College of Medicine, University of the Philippines Manila, Philippines.; Department of Epidemiology and Biostatistics, College of Public Health, University of the Philippines Manila, Philippines., Moalong KMC; Division of Adult Neurology, Department of the Neurosciences, Philippine General Hospital, University of the Philippines Manila, Philippines., Adiao KJB; Department of Internal Medicine, Medical Center Manila, Philippines. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of clinical neuromuscular disease [J Clin Neuromuscul Dis] 2023 Dec 01; Vol. 25 (2), pp. 81-84. |
| DOI: | 10.1097/CND.0000000000000459 |
| Abstrakt: | Abstract: Isaac syndrome is one of the rare peripheral nerve hyperexcitability (PNH) syndromes, which manifests with gross fasciculations, muscle undulation, twitching, and cramps, with or without autonomic and sensory symptoms. The diagnosis relies on characteristic electromyogram findings and the presence of anti-leucine-rich glial inactivated 1 and anti-contactin-associated protein 2 antibodies in the serum. Here, we report the case of a 21-year-old woman, who presented with extremities and tongue myokymia whose electromyogram findings were compatible with PNH, albeit seronegative for antibodies. Neuromuscular ultrasound was performed showing high-frequency rotatory, to-and-fro, high-amplitude movement of superficial and deep muscle fascicles, more prominent in the proximal than distal muscles. Neuromuscular ultrasound may be a useful adjunct in the diagnosis of PNH. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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