Perioperative complications of using freezing nitrogen ethanol composite to treat bone tumors: Clinical experience from a single center.

Autor:	Chen YC; Department of Orthopedics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, ROC.; Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC., Chen CM; Department of Orthopedics and Joint Reconstruction, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Orthopedic Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Chen KL; Department of Orthopedics and Joint Reconstruction, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Orthopedic Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Wang PH; Department of Orthopedics and Joint Reconstruction, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Orthopedic Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Chen CF; Department of Orthopedics and Joint Reconstruction, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Orthopedic Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Wu PK; Department of Orthopedics and Joint Reconstruction, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Orthopedic Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Chen WM; Department of Orthopedics and Joint Reconstruction, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Orthopedic Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Jazyk:	angličtina
Zdroj:	Journal of the Chinese Medical Association : JCMA [J Chin Med Assoc] 2024 Jan 01; Vol. 87 (1), pp. 64-69. Date of Electronic Publication: 2023 Nov 10.
DOI:	10.1097/JCMA.0000000000001018
Abstrakt:	Background: The cryoablation efficacy of semisolid freezing nitrogen ethanol composite (FNEC) has been demonstrated. We aimed to investigate the feasibility of adjuvant FNEC-assisted cryoablation in different bone cavity types by assessing the perioperative complication rates. Methods: The medical charts of patients who received intraoperative adjuvant cryoablation using semisolid FNEC for bone tumors from December 2013 to January 2018 were reviewed. The bone cavities were categorized into three types according to liquid spill potential (type 1, able to hold liquid without limb manipulation; type 2, required extensive limb manipulation to retain liquid; type 3, unable to retain liquid). The overall complication rate and the complication rates stratified by bone cavity type were determined. Results: Among the 76 patients, 30.3%, 57.9%, and 11.8% had type 1, 2, and 3 bone cavities, respectively. The mean follow-up time for perioperative complications was 43.5 ± 24.1 days. Five patients experienced complications, including two cases of skin damage, two cases of skin infection, and one case of fracture, yielding an overall perioperative complication rate of 6.4%. All cases of skin damage and skin infection were superficial and manageable by oral antibiotics. The patient with a pathologic fracture recovered well after being treated with open reduction and plate fixation. No neuropraxia was noted within the first few days postsurgery in any patient. The complication rates in type 1, 2, and 3 bone cavities were 13%, 4.6%, and 0%, respectively. Conclusion: All bone cavity types had a low incidence of perioperative complications after treatment with adjuvant FNEC-assisted cryoablation. Semisolid FNEC-assisted cryoablation is a feasible alternative to overcome the liquid spill potential in bone cavities resulting from tumor resection and intralesional curettage. Competing Interests: Conflicts of interest: Dr. Po-Kuei Wu and Dr. Wei-Ming Chen, editorial board members at Journal of the Chinese Medical Association , have no roles in the peer review process of or decision to publish this article. The other authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article. (Copyright © 2023, the Chinese Medical Association.)
Databáze:	MEDLINE
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