Probiotics for infantile colic: Is there evidence beyond doubt? A meta-analysis and systematic review.

Autor: Vaz SR; School of Medicine, Federal University of Goiás, Goiânia, Brazil., Tofoli MH; Department of Pediatric Gastroenterology, State Hospital for Children and Adolescents, Goiânia, Brazil., Avelino MAG; Department of Otorhinolaryngology, Federal University of Goiás, Goiânia, Brazil., da Costa PSS; Department of Pediatrics, Federal University of Goiás, Goiânia, Brazil.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Feb; Vol. 113 (2), pp. 170-182. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1111/apa.17036
Abstrakt: Aim: This study is a systematic review and meta-analysis of randomised controlled trials that employed probiotics and symbiotics for treating infantile colic.
Methods: We performed electronic systematic literature searches in Embase, PubMed and Web of Science, to identify articles published between 1950 and April 2023. Only RCT involving infants with infantile colic under 3 months were included. The treatment plan comprised 15 probiotics, which included Lactobacillus reuteri DSM 17938 and Bifidobacterium animalis lactis BB-12. The probiotics were administered alone or in combination with a prebiotic, vs. no intervention or a placebo.
Results: Probiotics resulted in an average reduction of 51 min of crying per day (p = 0.001). Further analysis of subgroups showed that the reduction was -39.30 min for vaginal delivery (p = 0.003), -64.66 min for Lactobacillus reuteri DSM 17938 (p = 0.03), -40.45 min for other strains (p < 0.00001), -74.28 min for exclusively breastfed infants (p = 0.0003) and -48.04 min for mixed feeding (p < 0.00001).
Conclusion: All probiotic strains seem effective in treating infantile colic. Exclusively breastfed infants have demonstrated more significant reduction in crying time. However, the available evidence on the effectiveness of probiotics in formula-fed and caesarean-born infants is limited.
(© 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: