Associations Between Polygenic Scores for Cognitive and Non-cognitive Factors of Educational Attainment and Measures of Behavior, Psychopathology, and Neuroimaging in the Adolescent Brain Cognitive Development Study.

Autor:	Gorelik AJ; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Paul SE; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Miller AP; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Baranger DAA; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Lin S; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Zhang W; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States., Elsayed NM; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Modi H; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Addala P; Department of Psychology, Emory University, Atlanta, GA, USA., Bijsterbosch J; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States., Barch DM; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Karcher NR; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Hatoum AS; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Agrawal A; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA., Bogdan R; Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA., Johnson EC; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2023 Oct 28. Date of Electronic Publication: 2023 Oct 28.
DOI:	10.1101/2023.10.27.23297675
Abstrakt:	Background: Both cognitive and non-cognitive (e.g., traits like curiosity) factors are critical for social and emotional functioning and independently predict educational attainment. These factors are heritable and genetically correlated with a range of health-relevant traits and behaviors in adulthood (e.g., risk-taking, psychopathology). However, whether these associations are present during adolescence, and to what extent these relationships diverge, could have implications for adolescent health and well-being. Methods: Using data from 5,517 youth of European ancestry from the ongoing Adolescent Brain Cognitive Development SM Study, we examined associations between polygenic scores (PGS) for cognitive and non-cognitive factors and outcomes related to cognition, socioeconomic status, risk tolerance and decision-making, substance initiation, psychopathology, and brain structure. Results: Cognitive and non-cognitive PGSs were both positively associated with cognitive performance and family income, and negatively associated with ADHD and severity of psychotic-like experiences. The cognitive PGS was also associated with greater risk-taking, delayed discounting, and anorexia, as well as lower likelihood of nicotine initiation. The cognitive PGS was further associated with cognition scores and anorexia in within-sibling analyses, suggesting these results do not solely reflect the effects of assortative mating or passive gene-environment correlations. The cognitive PGS showed significantly stronger associations with cortical volumes than the non-cognitive PGS and was associated with right hemisphere caudal anterior cingulate and pars-orbitalis in within-sibling analyses, while the non-cognitive PGS showed stronger associations with white matter fractional anisotropy and a significant within-sibling association for right superior corticostriate-frontal cortex. Conclusions: Our findings suggest that PGSs for cognitive and non-cognitive factors show similar associations with cognition and socioeconomic status as well as other psychosocial outcomes, but distinct associations with regional neural phenotypes in this adolescent sample. Competing Interests: COI. The authors report no conflicts of interest or competing interests.
Databáze:	MEDLINE
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