Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study.
| Autor: | Kerestes R; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia., Perry A; Monash Bioinformatics Platform, Monash University, Melbourne, VIC, Australia., Vivash L; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia., O'Brien TJ; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Medicine and Neurology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia., Alvim MKM; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Arienzo D; Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA., Aventurato ÍK; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Ballerini A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Baltazar GF; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Bargalló N; Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.; Department of Radiology of Center of Image Diagnosis (CDIC), Hospital Clinic de Barcelona, Barcelona, Spain.; CIBERSAM, Madrid, Spain., Bender B; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Brioschi R; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Bürkle E; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Caligiuri ME; Neuroscience Research Center, Department of Medical and Surgical Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy., Cendes F; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., de Tisi J; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK., Duncan JS; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK., Engel JP Jr; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Foley S; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK., Fortunato F; Institute of Neurology, Department of Medical and Surgical Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy., Gambardella A; Neuroscience Research Center, Department of Medical and Surgical Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Institute of Neurology, Department of Medical and Surgical Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy., Giacomini T; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy., Guerrini R; Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy., Hall G; School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom., Hamandi K; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.; The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK., Ives-Deliperi V; Neuroscience Institute, University of Cape Town, Cape Town, South Africa., João RB; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Keller SS; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; The Walton Centre NHS Foundation Trust, Liverpool, UK., Kleiser B; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Labate A; Neurophysiopatology and Movement Disorders Clinic, University of Messina, Messina, Italy.; Regional Epilepsy Center, University of Messina, Messina, Italy., Lenge M; Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.; Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy., Marotta C; Department of Neurology, Alfred Health, Melbourne, VIC, Australia., Martin P; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Mascalchi M; 'Mario Serio' Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy.; Division of Epidemiology and Clinical Governance, Institute for Study, Prevention and network in Oncology of the Tuscany Region, Florence, Italy., Meletti S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria Modena, Modena, Italy., Owens-Walton C; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Parodi CB; IRCCS Istituto 'Giannina Gaslini', Genova, Italy., Pascual-Diaz S; Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain., Powell D; Monash Bioinformatics Platform, Monash University, Melbourne, VIC, Australia., Rao J; Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA., Rebsamen M; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Reiter J; Department of Epileptology, University Hospital Bonn, Bonn, Germany., Riva A; IRCCS Istituto 'Giannina Gaslini', Genova, Italy., Rüber T; Department of Epileptology, University Hospital Bonn, Bonn, Germany., Rummel C; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Scheffler F; Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Severino M; IRCCS Istituto 'Giannina Gaslini', Genova, Italy., Silva LS; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Staba RJ; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Stein DJ; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Monash Bioinformatics Platform, Monash University, Melbourne, VIC, Australia.; Department of Medicine and Neurology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil.; Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain.; Department of Radiology of Center of Image Diagnosis (CDIC), Hospital Clinic de Barcelona, Barcelona, Spain.; CIBERSAM, Madrid, Spain.; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.; Neuroscience Research Center, Department of Medical and Surgical Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.; Institute of Neurology, Department of Medical and Surgical Sciences, University 'Magna Græcia' of Catanzaro, Catanzaro, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.; Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.; School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom.; The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; The Walton Centre NHS Foundation Trust, Liverpool, UK.; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Neurophysiopatology and Movement Disorders Clinic, University of Messina, Messina, Italy.; Regional Epilepsy Center, University of Messina, Messina, Italy.; Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Children's Hospital A. Meyer-University of Florence, Florence, Italy.; Department of Neurology, Alfred Health, Melbourne, VIC, Australia.; 'Mario Serio' Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy.; Division of Epidemiology and Clinical Governance, Institute for Study, Prevention and network in Oncology of the Tuscany Region, Florence, Italy.; Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria Modena, Modena, Italy.; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.; IRCCS Istituto 'Giannina Gaslini', Genova, Italy.; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department of Epileptology, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.; Epilepsy Society MRI Unit, Chalfont St Peter, UK.; Department of Medicine (Division of Neurology), Queen's University Kingston, ON, Canada.; Chalfont Centre for Epilepsy, Bucks, UK.; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia., Striano P; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.; IRCCS Istituto 'Giannina Gaslini', Genova, Italy., Taylor PN; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; School of Computing, Newcastle University, Newcastle upon Tyne, United Kingdom., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Tortora D; IRCCS Istituto 'Giannina Gaslini', Genova, Italy., Vaudano AE; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria Modena, Modena, Italy., Weber B; Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany., Wiest R; Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Winston GP; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Epilepsy Society MRI Unit, Chalfont St Peter, UK.; Department of Medicine (Division of Neurology), Queen's University Kingston, ON, Canada., Yasuda CL; Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Zheng H; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., McDonald CR; Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA., Sisodiya SM; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Bucks, UK., Harding IH; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 23. Date of Electronic Publication: 2023 Oct 23. |
| DOI: | 10.1101/2023.10.21.562994 |
| Abstrakt: | Objective: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current cortico-centric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural MRI in 1,602 adults with epilepsy and 1,022 healthy controls across twenty-two sites from the global ENIGMA-Epilepsy working group. Methods: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions. Linear mixed models compared total and regional cerebellar volume in i) all epilepsies; ii) temporal lobe epilepsy with hippocampal sclerosis (TLE-HS); iii) non-lesional temporal lobe epilepsy (TLE-NL); iv) genetic generalised epilepsy; and (v) extra-temporal focal epilepsy (ETLE). Relationships were examined for cerebellar volume versus age at seizure onset, duration of epilepsy, phenytoin treatment, and cerebral cortical thickness. Results: Across all epilepsies, reduced total cerebellar volume was observed ( d =0.42). Maximum volume loss was observed in the corpus medullare ( d Significance: We provide robust evidence of deep cerebellar and posterior lobe subregional grey matter volume loss in patients with chronic epilepsy. Volume loss was maximal for posterior subregions implicated in non-motor functions, relative to motor regions of both the anterior and posterior lobe. Associations between cerebral and cerebellar changes, and variability of neuroanatomical profiles across epilepsy syndromes argue for more precise incorporation of cerebellum subregions into neurobiological models of epilepsy. Competing Interests: L.Vivash. reports research funding from Biogen Australia, Life Molecular Imaging and Eisai. T.J. O’Brien has received consulting fees from Eisai, UCB, Supernus, Biogen, ES Therapeutics, Epidarex, LivaNova, Kinoxis Therapeutics. He participates on the Data Safety Monitoring Board for ES Therapeutics, Kinoxis Therapeutics. He has served as President (past) for Epilepsy Society of Australia, and is the current chair for Australian Epilepsy Clinical Trials Network (AECTN) and the American Epilepsy Society (Translational Research Committee). B. Bender is the cofounder of AIRAmed GmbH, a company that offers brain segmentation. P. Martin. has received honorary as an advisory board member from Biogen unrelated to the submitted work. P. Striano received speaker fees and advisory boards for Biomarin, Zogenyx, GW Pharmaceuticals; research funding by ENECTA BV, GW Pharmaceuticals, Kolfarma srl., Eisai. P.M. Thompson received a research grant from Biogen, Inc., and was a paid consultant for Kairos Venture Capital, Inc., USA, for projects unrelated to this work. C.L. Yasuda has received personal payments from Torrent, Zodiac and UCB. S.M Sisodiya has received research grants from UCB Pharma and Jazz Pharmaceuticals, speakers fees from UCB, Eisai and Zogenix; honoraria or other fees from Eisai, Jazz Pharma, Stoke Therapeutics, UCB and Zogenix. (payments to institution) The remaining authors have no conflicts of interest. |
| Databáze: | MEDLINE |
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