Temperature-driven coordination of circadian transcriptome regulation.

Autor:	Xu B; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, IL 60208, USA., Hwangbo DS; Department of Biology, University of Louisville, Louisville, KY 40292, USA.; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA., Saurabh S; Department of Biology, Loyola University, Chicago, IL 60660, USA., Rosensweig C; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, IL 60208, USA.; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA., Allada R; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, IL 60208, USA.; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA., Kath WL; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, IL 60208, USA.; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.; Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL 60208, USA., Braun R; Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.; NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, IL 60208, USA.; Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA.; Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA.; Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL 60208, USA.; Santa Fe Institute, Santa Fe, NM 87501, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 01. Date of Electronic Publication: 2023 Nov 01.
DOI:	10.1101/2023.10.27.563979
Abstrakt:	The circadian rhythm is an evolutionarily-conserved molecular oscillator that enables species to anticipate rhythmic changes in their environment. At a molecular level, the core clock genes induce a circadian oscillation in thousands of genes in a tissue-specific manner, orchestrating myriad biological processes. While studies have investigated how the core clock circuit responds to environmental perturbations such as temperature, the downstream effects of such perturbations on circadian regulation remain poorly understood. By analyzing bulk-RNA sequencing of Drosophila fat bodies harvested from flies subjected to different environmental conditions, we demonstrate a highly condition-specific circadian transcriptome. Further employing a reference-based gene regulatory network (Reactome), we find evidence of increased gene-gene coordination at low temperatures and synchronization of rhythmic genes that are network neighbors. Our results point to the mechanisms by which the circadian clock mediates the fly's response to seasonal changes in temperature.
Databáze:	MEDLINE
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