| Autor: |
Kronberg G; Icahn School of Medicine at Mount Sinai, New York, NY 10029., Ceceli AO; Icahn School of Medicine at Mount Sinai, New York, NY 10029., Huang Y; Icahn School of Medicine at Mount Sinai, New York, NY 10029., Gaudreault PO; Icahn School of Medicine at Mount Sinai, New York, NY 10029., King SG; Icahn School of Medicine at Mount Sinai, New York, NY 10029., McClain N; Icahn School of Medicine at Mount Sinai, New York, NY 10029., Alia-Klein N; Icahn School of Medicine at Mount Sinai, New York, NY 10029., Goldstein RZ; Icahn School of Medicine at Mount Sinai, New York, NY 10029. |
| Abstrakt: |
Movies captivate groups of individuals (the audience), especially if they contain themes of common motivational interest to the group. In drug addiction, a key mechanism is maladaptive motivational salience attribution whereby drug cues outcompete other reinforcers within the same environment or context. We predicted that while watching a drug-themed movie, where cues for drugs and other stimuli share a continuous narrative context, fMRI responses in individuals with heroin use disorder (iHUD) will preferentially synchronize during drug scenes. Results revealed such drug-biased synchronization in the orbitofrontal cortex (OFC), ventromedial and ventrolateral prefrontal cortex, and insula. After 15 weeks of inpatient treatment, there was a significant reduction in this drug-biased shared response in the OFC, which correlated with a concomitant reduction in dynamically-measured craving, suggesting synchronized OFC responses to a drug-themed movie as a neural marker of craving and recovery in iHUD. |
