Functional neuroimaging related to lower urinary tract sensations: Future directions for study designs and selection of patient groups: ICI-RS 2023.

Autor: de Rijk MM; Department of Urology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Urology, Maastricht University Medical Centre+, Maastricht, The Netherlands., Drake MJ; Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, London, UK., von Gontard A; Parent-Child and Adolescent Department, Hochgebirgsklinik, Davos, Switzerland.; Governor Kremers Centre, Department of Urology, Maastricht University Medical Centre+, Maastricht, The Netherlands., Solomon E; Urology Centre, Guy's and St Thomas' NHS Trust, London, UK.; Paediatric Nephro-Urology, Evelina Children's Hospital, London, UK., Dmochowski R; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Schurch B; Neuourology Unit, Clinique des Grangettes, Genève, Switzerland.; Department of Neuroscience, University Hospital Lausanne, Lausanne, Switzerland., van Koeveringe GA; Department of Urology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Urology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Jazyk: angličtina
Zdroj: Neurourology and urodynamics [Neurourol Urodyn] 2024 Aug; Vol. 43 (6), pp. 1400-1408. Date of Electronic Publication: 2023 Nov 13.
DOI: 10.1002/nau.25333
Abstrakt: Objectives: Neuroimaging studies have advanced our understanding of the intricate central nervous system control network governing lower urinary tract (LUT) function, shedding light on mechanisms for urine storage and voiding. However, a lack of consensus in methodological approaches hinders the comparability of results among research groups and limits the translation of this knowledge to clinical applications, emphasizing the need for standardized methodologies and clinical utilization guidelines.
Methods: This paper reports the discussions of a workshop at the 2023 meeting of the International Consultation on Incontinence Research Society, which reviewed uncertainties and research priorities to progress the field of neuroimaging in LUT control and dysfunction.
Results: Neuroimaging holds great potential for improving our understanding of LUT control and pathophysiological conditions. To date, functional neuroimaging techniques have not yet achieved sufficient strength to make a direct clinical impact. Potential approaches that can improve the clinical utilization of neuroimaging were discussed and research questions proposed.
Conclusions: Neuroimaging offers a valuable tool for investigating LUT control, but it's essential to acknowledge the potential for oversimplification when interpreting brain activity due to the complex neural processing and filtering of sensory information. Moreover, technical limitations pose challenges in assessing key brain stem and spinal cord centers, particularly in cases of neurological dysfunction, highlighting the need for more reliable imaging of these centers to advance our understanding of LUT function and dysfunction.
(© 2023 The Authors. Neurourology and Urodynamics published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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