| Autor: |
Sullivan KV; Atomic and Mass Spectrometry-A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium., Assantuh Y; Atomic and Mass Spectrometry-A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium., Grigoryan R; The Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA., Costas-Rodríguez M; Atomic and Mass Spectrometry-A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium.; Centro de Investigación Mariña, Departamento de Química Analítica y Alimentaria, Grupo QA2, Universidade de Vigo, 36310 Vigo, Spain., Bolea-Fernandez E; Atomic and Mass Spectrometry-A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium.; Department of Analytical Chemistry, Aragón Institute of Engineering Research (I3A), University of Zaragoza, 50009 Zaragoza, Spain., Lapauw B; Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium., Van Laecke S; Renal Division, Department of Internal Medicine and Pediatrics, Ghent University Hospital, 9000 Ghent, Belgium., Vanhaecke F; Atomic and Mass Spectrometry-A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, Belgium. |
| Abstrakt: |
Hypomagnesemia was historically prevalent in individuals with type 1 diabetes mellitus (T1DM), but contemporary results indicate an incidence comparable to that in the general population, likely due to improved treatment in recent decades, resulting in better glycemic control. However, a recent study found a significant difference between the serum Mg isotopic composition of T1DM individuals and controls, indicating that disruptions to Mg homeostasis persist. Significant deviations were also found in samples taken one year apart. To investigate whether the temporal variability in serum Mg isotopic composition is linked to the transient impact of administered insulin, Mg isotope ratios were determined in serum from 15 T1DM individuals before and one hour after insulin injection/meal consumption using multi-collector inductively coupled plasma-mass spectrometry. Consistent with results of the previous study, significant difference in the serum Mg isotopic composition was found between T1DM individuals and 10 sex-matched controls. However, the average difference between pre- and post-insulin injection/meal T1DM samples of 0.05 ± 0.13‱ (1SD) was not significant. No difference was observed for controls before (-0.12 ± 0.16‱) and after the meal (-0.10 ± 0.13‱) either, suggesting a lack of a postprandial Mg isotopic response within one hour of food consumption, and that the timing of the most recent meal may not require controlling for when determining serum Mg isotopic composition. |
