Bilateral retinal vasculitis due to presumed sarcoidosis with rickettsial retinitis.

Autor:	Mahendradas P; Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India., Acharya I; Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India., Mishra SB; Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India., Sanjay S; Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India., Kawali A; Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India., Shetty R; Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bengaluru, Karnataka, India., Ghosh A; GROW Research Laboratory, Narayana Nethralaya Eye Foundation, Bengaluru, Karnataka, India., Sethu S; GROW Research Laboratory, Narayana Nethralaya Eye Foundation, Bengaluru, Karnataka, India.
Jazyk:	angličtina
Zdroj:	European journal of ophthalmology [Eur J Ophthalmol] 2024 May; Vol. 34 (3), pp. NP116-NP121. Date of Electronic Publication: 2023 Nov 13.
DOI:	10.1177/11206721231212776
Abstrakt:	Objective: To describe a case of bilateral retinal vasculitis due to presumed sarcoidosis and rickettsial retinitis complicated with neovascularization with tear biomarker analysis. Methods: A retrospective case report. Results: A 16-year-old male presented with bilateral retinal vasculitis and retinitis in both eyes with inferotemporal quadrant neovascularization in the right eye. Multimodal imaging revealed the presence of active inflammation in both eyes. Weil Felix test was positive with raised ACE levels. This patient was treated with local and systemic steroids, doxycycline, and laser photocoagulation followed by oral methotrexate therapy which resulted in clinical resolution with recovery of visual acuity. Tear biomarker analysis showed raised sICAM-1 and MMP-9 levels in both eyes which significantly reduced following treatment. Conclusion: Ocular sarcoidosis with rickettsial infection is a rare association. Tear biomarkers correlated well with clinical and imaging manifestations. High index of suspicion and aggressive anti-inflammatory therapy can help control inflammation and restore good vision. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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