Trust-based health decision-making recruits the neural interoceptive saliency network which relates to temporal trajectories of Hemoglobin A1C in Diabetes Type 1.

Autor: Jorge H; PIDFIF - Inter-University PhD Program in Clinical Psychology, Family Psychology and Family Intervention, Faculty of Psychology and Educational Sciences of Coimbra and Faculty of Psychology of Lisbon, Portugal & Coimbra Institute for Biomedical Imaging and Translational Research, CIBIT/ ICNAS, University of Coimbra, Coimbra, Portugal., Duarte IC; Coimbra Institute for Biomedical Imaging and Translational Research, CIBIT/ ICNAS, University of Coimbra, Polo 3, 3000-548, Coimbra, Portugal., Melo M; Endocrinology, Diabetes and Metabolism Department (SEMD), University and Hospital Center of Coimbra, Coimbra, Portugal., Relvas AP; Faculty of Psychology and Educational Sciences & Center for Social Studies, University of Coimbra, Coimbra, Portugal., Castelo-Branco M; Coimbra Institute for Biomedical Imaging and Translational Research, CIBIT/ ICNAS, University of Coimbra, Polo 3, 3000-548, Coimbra, Portugal. mcbranco@fmed.uc.pt.; Endocrinology, Diabetes and Metabolism Department (SEMD), University and Hospital Center of Coimbra, Coimbra, Portugal. mcbranco@fmed.uc.pt.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Feb; Vol. 18 (1), pp. 171-183. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1007/s11682-023-00816-z
Abstrakt: Experimental approaches in neuroeconomics generally involve monetary utility. Utility in the health domain is relevant in diabetes because constant daily life decisions are critical for self-consequential long-term outcomes. We used fMRI to investigate self-consequent decision-making in the health and economic domains in Type 1 Diabetes Mellitus and controls (N = 50). We focused on two critical phases of decision-making: Investment and Feedback (Positive or Negative). Patients showed larger BOLD activation of limbic, and reward/dopaminergic regions in particular in the health trust game. Importantly, the worse the trajectory of metabolic control (increasing HbA1C), the higher the BOLD activity in regions of the interoceptive saliency network. This was manifested by positive correlations between brain activity during investment in anterior cingulate cortex and insula and HbA1c blood level progression. We conclude that the neural correlates of health-consequent decision-making domain involve limbic and reward related dopaminergic regions in Type 1 Diabetes Mellitus. Furthermore, the temporal trajectory of HbA1C blood levels is correlated with neural risk processing in the saliency network. Evidence for differential risk processing in the health versus the neuroeconomic context, and the discovery of a role for the saliency interoceptive network in metabolic control trajectories suggests a new perspective on the development of personalized interventions.
(© 2023. The Author(s).)
Databáze: MEDLINE
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