Solitary fibrous tumours involving the genitourinary tract: a case series in rare locations, highlighting the role of STAT6 immunohistochemistry.

Autor: Lobo J; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC), R. Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal. jpedro.lobo@ipoporto.min-saude.pt.; Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC) & RISE@CI-IPOP (Health Research Network), R. Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal. jpedro.lobo@ipoporto.min-saude.pt.; Department of Pathology and Molecular Immunology, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Rua Jorge Viterbo Ferreira 228, 4050-513, Porto, Portugal. jpedro.lobo@ipoporto.min-saude.pt., Harik LR; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Peyton CC; Department of Urology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA., Morini MA; Instituto D'Or de Pesquisa e Ensino (IDOR), São Paulo, Brazil., Zein-Sabatto B; Department of Pathology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, AL, USA., Winokur T; Department of Pathology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, AL, USA., Zotto VD; Department of Pathology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, AL, USA., Magi-Galluzzi C; Department of Pathology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, AL, USA. cmagigalluzzi@uabmc.edu.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Apr; Vol. 484 (4), pp. 697-702. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1007/s00428-023-03694-4
Abstrakt: Solitary fibrous tumour (SFT) is a mesenchymal neoplasm with variable behaviour, very rarely involving the genitourinary (GU) tract. Most reported cases correspond to isolated case reports. STAT6 immunohistochemistry is a more recent and reliable diagnostic marker. The pathology database of two tertiary institutes was searched for SFTs involving the GU tract. STAT6 strong diffuse nuclear staining confirmed the diagnosis in all four cases, and the NAB2::STAT6 fusion was demonstrated by NGS in one case. Two cases were diagnosed in needle biopsy, one involving the prostate and the other involving the seminal vesicle. One case corresponded to a pelvic mass inseparable from and infiltrating the prostate and bladder. The remainder represented an exceedingly rare involvement of the spermatic cord. Involvement by a SFT should be considered in the differential diagnosis of spindle cell lesions involving GU organs. STAT6 strong diffuse nuclear staining is an important ancillary tool, particularly in a biopsy.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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