Genomics of Plasmodium vivax in Colombia reveals evidence of local bottle-necking and inter-country connectivity in the Americas.

Autor: Sutanto E; Exeins Health Initiative, Jakarta, Indonesia., Pava Z; Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Echeverry DF; Departamento de Microbiología, Universidad del Valle, Cali, Colombia.; International Training and Medical Research Center (CIDEIM), Cali, Colombia., Lopera-Mesa TM; Universidad de Antioquia, Medellín, Colombia., Montenegro LM; Universidad de Antioquia, Medellín, Colombia., Yasnot-Acosta MF; Grupo de Investigaciones Microbiológicas y Biomédicas de Córdoba (GIMBIC), Universidad de Córdoba, Monteria, Colombia., Benavente ED; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands., Pearson RD; Wellcome Sanger Institute, Cambridge, UK., Herrera S; Caucaseco Scientific Research Center, Cali, Colombia., Arévalo-Herrera M; Caucaseco Scientific Research Center, Cali, Colombia.; Centro Internacional de Vacunas, Cali, Colombia., Trimarsanto H; Menzies School of Health Research and Charles Darwin University, Darwin, Australia.; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Rumaseb A; Menzies School of Health Research and Charles Darwin University, Darwin, Australia., Noviyanti R; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Kwiatkowski DP; Wellcome Sanger Institute, Cambridge, UK., Price RN; Menzies School of Health Research and Charles Darwin University, Darwin, Australia.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Auburn S; Menzies School of Health Research and Charles Darwin University, Darwin, Australia. Sarah.Auburn@menzies.edu.au.; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. Sarah.Auburn@menzies.edu.au.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Sarah.Auburn@menzies.edu.au.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 13; Vol. 13 (1), pp. 19779. Date of Electronic Publication: 2023 Nov 13.
DOI: 10.1038/s41598-023-46076-1
Abstrakt: Colombia aims to eliminate malaria by 2030 but remains one of the highest burden countries in the Americas. Plasmodium vivax contributes half of all malaria cases, with its control challenged by relapsing parasitaemia, drug resistance and cross-border spread. Using 64 Colombian P. vivax genomes collected between 2013 and 2017, we explored diversity and selection in two major foci of transmission: Chocó and Córdoba. Open-access data from other countries were used for comparative assessment of drug resistance candidates and to assess cross-border spread. Across Colombia, polyclonal infections were infrequent (12%), and infection connectivity was relatively high (median IBD = 5%), consistent with low endemicity. Chocó exhibited a higher frequency of polyclonal infections (23%) than Córdoba (7%), although the difference was not significant (P = 0.300). Most Colombian infections carried double pvdhfr (95%) and single pvdhps (71%) mutants, but other drug resistance mutations were less prevalent (< 10%). There was no evidence of selection at the pvaat1 gene, whose P. falciparum orthologue has recently been implicated in chloroquine resistance. Global population comparisons identified other putative adaptations. Within the Americas, low-level connectivity was observed between Colombia and Peru, highlighting potential for cross-border spread. Our findings demonstrate the potential of molecular data to inform on infection spread and adaptation.
(© 2023. The Author(s).)
Databáze: MEDLINE
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