Ultrafine particulate matter exposure during second year of life, but not before, associated with increased risk of autism spectrum disorder in BKMR mixtures model of multiple air pollutants.

Autor: Goodrich AJ; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA. Electronic address: ajgoodrich@ucdavis.edu., Kleeman MJ; Department of Civil and Environmental Engineering, University of California Davis, Sacramento, CA, USA., Tancredi DJ; Department of Pediatrics, University of California Davis, Sacramento, CA, USA., Ludeña YJ; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA., Bennett DH; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA., Hertz-Picciotto I; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA., Schmidt RJ; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Feb 01; Vol. 242, pp. 117624. Date of Electronic Publication: 2023 Nov 11.
DOI: 10.1016/j.envres.2023.117624
Abstrakt: Prenatal and early postnatal air pollution exposures have been shown to be associated with autism spectrum disorder (ASD) risk but results regarding specific air pollutants and exposure timing are mixed and no study has investigated the effects of combined exposure to multiple air pollutants using a mixtures approach. We aimed to evaluate prenatal and early life multipollutant mixtures for the drivers of associations of air pollution with ASD. This study examined 484 typically developing (TD) and 660 ASD children from the CHARGE case-control study. Daily air concentrations for NO 2 , O 3 , ultrafine (PM 0.1 ), fine (PM 0.1-2.5 ), and coarse (PM 2.5-10 ) particles were predicted from chemical transport models with statistical bias adjustment based on ground-based monitors. Daily averages were calculated for each exposure period (pre-pregnancy, each trimester of pregnancy, first and second year of life) between 2000 and 2016. Air pollution variables were natural log-transformed and then standardized. Individual and joint effects of pollutant exposure with ASD, and potential interactions, were evaluated for each period using hierarchical Bayesian Kernel Machine Regression (BKMR) models, with three groups: PM size fractions (PM 0.1 , PM 0.1-2.5 , PM 2.5-10 ), NO 2 , and O 3 . In BKMR models, the PM group was associated with ASD in year 2 (group posterior inclusion probability (gPIP) = 0.75), and marginally associated in year 1 (gPIP = 0.497). PM 2.5-10 appeared to drive the association (conditional PIP (cPIP) = 0.64) in year 1, while PM 0.1 appeared to drive the association in year 2 (cPIP = 0.76), with both showing a moderately strong increased risk. Pre-pregnancy O 3 showed a slight J-shaped risk of ASD (gPIP = 0.55). No associations were observed for exposures during pregnancy. Pre-pregnancy O 3 and year 2 p.m. 0.1 exposures appear to be associated with an increased risk of ASD. Future research should examine ultrafine particulate matter in relation to ASD.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Daniel Tancredi reports a relationship with International Flavors & Fragrances Inc that includes: consulting or advisory. Daniel Tancredi reports a relationship with Synbiotic Health that includes: consulting or advisory. Rebecca J Schmidt reports a relationship with Beasley Allen Law Firm that includes: consulting or advisory. Rebecca J Schmidt reports a relationship with MotherToBaby - The Organization of Teratology Information Specialists (OTIS) that includes: travel reimbursement. Rebecca J Schmidt reports a relationship with Simons Foundation Autism Research Initiative that includes: funding grants. Rebecca J Schmidt reports a relationship with St. Johns - Centre for Advanced Research and Excellence in Autism and Developmental Disorders that includes: travel reimbursement. Rebecca J Schmidt reports a relationship with National Institutes of Health that includes: travel reimbursement.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
Externí odkaz: