Efficacy of Acupuncture for Chronic Spontaneous Urticaria : A Randomized Controlled Trial.

Autor:	Zheng H; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Xiao XJ; College of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China (X.-J.X.)., Shi YZ; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Zhang LX; Internal Medicine of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China (L.-X.Z.)., Cao W; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Zheng QH; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Zhong F; The First Hospital of Hunan University of Chinese Medicine, Changsha, China (F.Z., W.Z.)., Hao PS; Dermatology Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China (P.-S.H., Y.H., M.-L.C.)., Huang Y; Dermatology Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China (P.-S.H., Y.H., M.-L.C.)., Chen ML; Dermatology Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China (P.-S.H., Y.H., M.-L.C.)., Zhang W; The First Hospital of Hunan University of Chinese Medicine, Changsha, China (F.Z., W.Z.)., Zhou SY; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Wang YJ; Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang, China (Y.-J.W.)., Wang C; Wuhan No. 1 Hospital, Wuhan, China (C.W., L.Z.)., Zhou L; Wuhan No. 1 Hospital, Wuhan, China (C.W., L.Z.)., Chen XQ; No. 3 Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District), Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, China (X.-Q.C., Z.-Q.Y.)., Yang ZQ; No. 3 Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District), Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, China (X.-Q.C., Z.-Q.Y.)., Zou ZH; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Zhao L; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Liang FR; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.)., Li Y; Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China (H.Z., Y.-Z.S., W.C., Q.-H.Z., S.-Y.Z., Z.-H.Z., L.Z., F.-R.L., Y.L.).
Jazyk:	angličtina
Zdroj:	Annals of internal medicine [Ann Intern Med] 2023 Dec; Vol. 176 (12), pp. 1617-1624. Date of Electronic Publication: 2023 Nov 14.
DOI:	10.7326/M23-1043
Abstrakt:	Background: The effectiveness of acupuncture for patients with chronic spontaneous urticaria (CSU), reported in a few small-scale studies, is not convincing. Objective: To investigate whether acupuncture leads to better effects on CSU than sham acupuncture or waitlist control. Design: A multicenter, randomized, sham-controlled trial. (Chinese Clinical Trial Registry: ChiCTR1900022994). Setting: Three teaching hospitals in China from 27 May 2019 to 30 July 2022. Participants: 330 participants diagnosed with CSU. Intervention: Participants were randomly assigned in a 1:1:1 ratio to receive acupuncture, sham acupuncture, or waitlist control over an 8-week study period (4 weeks for treatment and another 4 weeks for follow-up). Measurements: The primary outcome was the mean change from baseline in the Weekly Urticaria Activity Score (UAS7) at week 4. Secondary outcomes included itch severity scores, self-rated improvement, and Dermatology Life Quality Index scores. Results: The mean change in UAS7 (range, 0 to 42) for acupuncture from baseline (mean score, 23.5 [95% CI, 21.8 to 25.2]) to week 4 (mean score, 15.3 [CI, 13.6 to 16.9]) was -8.2 (CI, -9.9 to -6.6). The mean changes in UAS7 for sham acupuncture and waitlist control from baseline (mean scores, 21.9 [CI, 20.2 to 23.6] and 22.1 [CI, 20.4 to 23.8], respectively) to week 4 (mean scores, 17.8 [CI, 16.1 to 19.5] and 20.0 [CI, 18.3 to 21.6], respectively) were -4.1 (CI, -5.8 to -2.4) and -2.2 (CI, -3.8 to -0.5), respectively. The mean differences between acupuncture and sham acupuncture and waitlist control were -4.1 (CI, -6.5 to -1.8) and -6.1 (CI, -8.4 to -3.7), respectively, which did not meet the threshold for minimal clinically important difference. Fifteen participants (13.6%) in the acupuncture group and none in the other groups reported adverse events. Adverse events were mild or transient. Limitation: Lack of complete blinding, self-reported outcomes, limited generalizability because antihistamine use was disallowed, and short follow-up period. Conclusion: Compared with sham acupuncture and waitlist control, acupuncture produced a greater improvement in UAS7, although the difference from control was not clinically significant. Increased adverse events were mild or transient. Primary Funding Source: The National Key R&D Program of China and the Science and Technology Department of Sichuan Province. Competing Interests: Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M23-1043.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu