Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBI.

Autor: Guerrero-Gonzalez JM; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. jguerrerogon@wisc.edu.; Waisman Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI, 53705, USA. jguerrerogon@wisc.edu., Kirk GR; Waisman Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI, 53705, USA., Birn R; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Bigler ED; Department of Psychology and Neuroscience Center, Brigham Young University, Provo, UT, USA.; Department of Neurology & Department of Psychiatry, University of Utah, Salt Lake City, UT, USA., Bowen K; Seattle Children's Hospital, Seattle, WA, USA., Broman AT; Department of Biostatistics, University of Wisconsin-Madison, Madison, WI, USA., Rosario BL; Department of Epidemiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Butt W; Department of Critical Care, Faculty of Medicine, Melbourne University, Melbourne, Australia., Beers SR; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bell MJ; Department of Pediatrics, Children's National Medical Center, Washington, DC, USA., Alexander AL; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI, 53705, USA., Ferrazzano PA; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, WI, 53705, USA.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Feb; Vol. 18 (1), pp. 159-170. Date of Electronic Publication: 2023 Nov 13.
DOI: 10.1007/s11682-023-00818-x
Abstrakt: This investigation explores memory performance using the California Verbal Learning Test in relation to morphometric and connectivity measures of the memory network in severe traumatic brain injury. Twenty-two adolescents with severe traumatic brain injury were recruited for multimodal MRI scanning 1-2 years post-injury at 13 participating sites. Analyses included hippocampal volume derived from anatomical T1-weighted imaging, fornix white matter microstructure from diffusion tensor imaging, and hippocampal resting-state functional magnetic resonance imaging connectivity as well as diffusion-based structural connectivity. A typically developing control cohort of forty-nine age-matched children also underwent scanning and neurocognitive assessment. Results showed hippocampus volume was decreased in traumatic brain injury with respect to controls. Further, hippocampal volume loss was associated with worse performance on memory and learning in traumatic brain injury subjects. Similarly, hippocampal fornix fractional anisotropy was reduced in traumatic brain injury with respect to controls, while decreased fractional anisotropy in the hippocampal fornix also was associated with worse performance on memory and learning in traumatic brain injury subjects. Additionally, reduced structural connectivity of left hippocampus to thalamus and calcarine sulcus was associated with memory and learning in traumatic brain injury subjects. Functional connectivity in the left hippocampal network was also associated with memory and learning in traumatic brain injury subjects. These regional findings from a multi-modal neuroimaging approach should not only be useful for gaining valuable insight into traumatic brain injury induced memory and learning disfunction, but may also be informative for monitoring injury progression, recovery, and for developing rehabilitation as well as therapy strategies.
(© 2023. The Author(s).)
Databáze: MEDLINE
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