Associations of quantitative contrast sensitivity with wide-field swept-source optical coherence tomography angiography in retinal vein occlusion.

Autor: Razavi P; Harvard Retinal Imaging Lab, Boston, MA, USA., Baldwin G; Harvard Retinal Imaging Lab, Boston, MA, USA., Vingopoulos F; Harvard Retinal Imaging Lab, Boston, MA, USA., Garg I; Harvard Retinal Imaging Lab, Boston, MA, USA., Tracy J; Harvard Retinal Imaging Lab, Boston, MA, USA., Wescott H; Harvard Retinal Imaging Lab, Boston, MA, USA., Choi H; Harvard Retinal Imaging Lab, Boston, MA, USA., Zeng R; Harvard Retinal Imaging Lab, Boston, MA, USA., Lains I; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Husain D; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Kim LA; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Vavvas DG; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Miller JB; Harvard Retinal Imaging Lab, Boston, MA, USA. John_Miller@meei.harvard.edu.; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA. John_Miller@meei.harvard.edu.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Mar; Vol. 262 (3), pp. 789-799. Date of Electronic Publication: 2023 Nov 13.
DOI: 10.1007/s00417-023-06288-7
Abstrakt: Purpose: To investigate associations between contrast sensitivity (CS) and vascular metrics on wide-field swept-source optical coherence tomography angiography (WF-SS-OCTA) in patients with retinal vein occlusion (RVO).
Methods: This prospectively recruited, cross-sectional observational study included RVO patients who underwent quantitative CS function (qCSF) testing and WF-SS-OCTA using 3 × 3, 6 × 6, and 12 × 12 mm angiograms on the same day. The study measured several qCSF outcomes and WF-SS-OCTA vascular metrics, including vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ). The data were analyzed using multivariable regression analysis controlling for age and central subfield thickness (CST).
Results: A total of 43 RVO eyes of 43 patients and 30 fellow eyes were included. In RVO eyes, multiple vascular metrics were associated with CS outcomes but not visual acuity (VA). On 12 × 12 images, CS thresholds at 1 cpd, 1.5 cpd, and 3 cpd were significantly associated with VD and VSD, but VA was not. When comparing standardized regression coefficients, we found that vascular metrics had a larger effect size on CS than on VA. For instance, the standardized beta coefficient for FAZ area and CS at 6 cpd (β* = - 0.46, p = 0.007) was larger than logMAR VA (β* = 0.40, p = 0.011).
Conclusion: Microvascular changes on WF-SS-OCTA in RVO had a larger effect size on CS than VA. This suggests CS may better reflect the microvascular changes of RVO compared to VA. qCSF-measured CS might be a valuable adjunct functional metric in evaluating RVO patients.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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