| Autor: |
Sant' Ana CT; Department of Food Technology, Federal University of Viçosa, Viçosa, MG36570-000, Brazil., Verediano TA; Department of Nutrition and Health, Federal University of Viçosa, Viçosa, MG, Brazil., Grancieri M; Department of Nutrition and Health, Federal University of Viçosa, Viçosa, MG, Brazil., Lopes Toledo RC; Department of Nutrition and Health, Federal University of Viçosa, Viçosa, MG, Brazil., Costa NMB; Department of Pharmacy and Nutrition, Federal University of Espírito Santo, Alegre, ES, Brazil., Martino HSD; Department of Nutrition and Health, Federal University of Viçosa, Viçosa, MG, Brazil., Barros FAR; Department of Food Technology, Federal University of Viçosa, Viçosa, MG36570-000, Brazil. |
| Abstrakt: |
Macauba ( Acrocomia aculeata ) is a palm tree native from Brazil, whose pulp is rich in oil that has a high content of oleic acid and carotenoids. Macauba pulp oil can bring health benefits due to its bioactive compounds; however, its effects on gut health are unknown. Thus, the objective of this study was to evaluate the effect of macauba pulp oil on the intestinal health in mice fed a high-fat (HF) diet. Male C57BL1/6 mice were randomly divided into three groups (10 animals/group): control diet, HF diet and HF diet with 4 % of macauba pulp oil (HFM). Concentration of short-chain fatty acids (SCFA), faecal pH and histomorphometric analysis of the colon were performed. Content of colon samples was used on microbiome analysis using 16S rRNA amplicon sequencing. Animals from the HFM group had higher butyric acid content and goblet cells number, greater circular and longitudinal muscle layer and higher α -diversity compared with the HF group. Moreover, consumption of MPO reduced Desulfobacterota phylum, Ruminococcaceae , Oscillospiraceae , Prevotellaceae , Bifidobacteriaceae family, Faecalibacterium , Prevotella , Ruminococcus and Enterorhabdus genus. Therefore, macauba pulp oil was able to modulate the gut microbiota and enhance intestinal barrier morphology, showing preventive effects on gut dysbiosis in mice fed a HF diet. |
