Sub-acute toxicity evaluation of aqueous leaf extract from Passiflora edulis Sims f. edulis (Gulupa) in Wistar rats.

Autor:	Rodríguez-Usaquén A; Grupo de Bioquímica Experimental y Computacional, Laboratorio de Neurobioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia., Sutachan JJ; Grupo de Bioquímica Experimental y Computacional, Laboratorio de Neurobioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia., Villarreal W; Grupo de Investigación Fitoquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia., Costa GM; Grupo de Investigación Fitoquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia., Acero Mondragon EJ; Grupo PROSEIM, Departamento de Morfofisiología, Facultad de Medicina, Universidad de La Sabana, Chía, Colombia., Ballesteros-Ramírez R; Grupo de Inmunobiología y Biología Celular, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia., Albarracín SL; Grupo de Bioquímica Experimental y Computacional, Laboratorio de Neurobioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2023 Oct 24; Vol. 11, pp. 396-404. Date of Electronic Publication: 2023 Oct 24 (Print Publication: 2023).
DOI:	10.1016/j.toxrep.2023.10.013
Abstrakt:	The genus Passiflora (Passifloraceae) comprises about 500 species. The Passiflora edulis stands out because of its economic and medicinal importance. It is widely planted in tropical and subtropical regions worldwide, especially in South America, the Caribbean, South Africa, and Asia. The aqueous extract of Passiflora edulis Sims f. edulis (Gulupa) leaves is used in traditional medicine for its soothing and tranquilizing effects on the central nervous system. Therefore, evaluating its safety for human use is a fundamental requirement to continue the development of new therapies within the framework of regulatory, preclinical, and clinical guidelines. Here, the sub-acute toxicity study was conducted following the Organization for Economic Cooperation and Development (OECD) guideline 407 for 28 days in Wistar albino rats. The study showed that 1000 mg/kg/day of the aqueous extract in 10 adult Wistar rats (five males and five females) was well tolerated. The hematological results are at normal levels. However, monocytopenia and eosinopenia were observed with a significant difference (P < 0,05) for both male and female rats treated with the aqueous extract of Passiflora edulis . The results show that liver and kidney function profiles were conserved. However, an increase in ALT is observed with significant differences between male and female rats treated with the extract compared to the controls. Study findings were limited to non-adverse histopathological results of a slightly increased incidence of focal periportal lymphocytic infiltrate in the liver and focal corticomedullary nephrocalcinosis in the kidney compared to control. Therefore, the aqueous extract of Passiflora edulis has a good safety profile in oral administration, was well tolerated, and did not cause any lethality or adverse effects in the sub-acute toxicity study in male and female rats. The NOAEL (no observed adverse effect level) for the 28-day subacute toxicity study was considered to be 1000 mg/kg. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors. Published by Elsevier B.V.)
Databáze:	MEDLINE
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