Breathing and Oxygen Carrying Capacity in Ts65Dn and Down Syndrome.

Autor: DeRuisseau LR; Department of Basic Sciences, University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA., Receno CN; Department of Exercise Science and Athletic Training, Ithaca College, Ithaca, NY 14850, USA., Cunningham C; Department of Statistics, Mathematics and Computer Science, Le Moyne College, Syracuse, NY 13214, USA., Bates ML; Departments of Health and Human Physiology, Internal Medicine, and the Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA., Goodell M; Lake Erie College of Osteopathic Medicine, Elmira, NY 14901, USA., Liang C; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642,USA., Eassa B; Department of Biological Sciences, Le Moyne College, Syracuse, NY 13214, USA., Pascolla J; Department of Basic Sciences, University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA., DeRuisseau KC; Department of Basic Sciences, University of Health Sciences and Pharmacy, St. Louis, MO 63110, USA.
Jazyk: angličtina
Zdroj: Function (Oxford, England) [Function (Oxf)] 2023 Oct 06; Vol. 4 (6), pp. zqad058. Date of Electronic Publication: 2023 Oct 06 (Print Publication: 2023).
DOI: 10.1093/function/zqad058
Abstrakt: Individuals with Down syndrome (Ds) are at increased risk of respiratory infection, aspiration pneumonia, and apnea. The Ts65Dn mouse is a commonly used model of Ds, but there have been no formal investigations of awake breathing and respiratory muscle function in these mice. We hypothesized that breathing would be impaired in Ts65Dn vs. wild-type (WT), and would be mediated by both neural and muscular inputs. Baseline minute ventilation was not different at 3, 6, or 12 mo of age. However, V T /T i , a marker of the neural drive to breathe, was lower in Ts65Dn vs. WT and central apneas were more prevalent. The response to breathing hypoxia was not different, but the response to hypercapnia was attenuated, revealing a difference in carbon dioxide sensing, and/or motor output in Ts65Dn. Oxygen desaturations were present in room air, demonstrating that ventilation may not be sufficient to maintain adequate oxygen saturation in Ts65Dn. We observed no differences in arterial P O2 or P CO2 , but Ts65Dn had lower hemoglobin and hematocrit. A retrospective medical record review of 52,346 Ds and 52,346 controls confirmed an elevated relative risk of anemia in Ds. We also performed eupneic in-vivo electromyography and in-vitro muscle function and histological fiber typing of the diaphragm, and found no difference between strains. Overall, conscious respiration is impaired in Ts65Dn, is mediated by neural mechanisms, and results in reduced hemoglobin saturation. Oxygen carrying capacity is reduced in Ts65Dn vs. WT, and we demonstrate that individuals with Ds are also at increased risk of anemia.
Competing Interests: None of the authors has any conflict of interest.
(© The Author(s) 2023. Published by Oxford University Press on behalf of American Physiological Society.)
Databáze: MEDLINE
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