Methanol extract of Iraqi Kurdistan Region Daphne mucronata as a potent source of antioxidant, antimicrobial, and anticancer agents for the synthesis of novel and bioactive polyvinylpyrrolidone nanofibers.

Autor:	Muzammil K; Department of Public Health, College of Applied Medical Sciences, Khamis Mushait Campus, King Khalid University, Abha, Saudi Arabia., Kzar MH; College of Physical Education and Sport Sciences, Al-Mustaqbal University, Hillah, Iraq., Mohammed F; Department of Medical Laboratories, Al-Manara College For Medical Sciences, Maysan, Iraq., Mohammed ZI; Department of Radiology and Sonar Techniques, Al-Noor University College, Nineveh, Iraq., Hamood SA; Department of Medical Engineering, Al-Esraa University College, Baghdad, Iraq., Hussein TK; Department of Medical Laboratories, Al-Hadi University College, Baghdad, Iraq., Hanoon SJ; Department of Medical Laboratories, College of Health and Medical Technology, Sawa University, Almuthana, Iraq., Qasim MT; Department of Anesthesia, College of Health and Medical Technololgy, Al-Ayen University, Thi-Qar, Iraq., Hussien Alawadi A; College of Technical Engineering, The Islamic University, Najaf, Iraq.; College of Technical Engineering, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq., Alsalamy A; College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq.
Jazyk:	angličtina
Zdroj:	Frontiers in chemistry [Front Chem] 2023 Oct 25; Vol. 11, pp. 1287870. Date of Electronic Publication: 2023 Oct 25 (Print Publication: 2023).
DOI:	10.3389/fchem.2023.1287870
Abstrakt:	In this study, aqueous, ethanol, methanol, and hexane extracts from Iraqi Kurdistan Region Daphne mucronata were prepared due to the numerous applications and development of nanofibers in biological and medical fields, including food packaging, enzyme stabilization, and wound dressing. In the initial evaluation of the extracts, the antioxidant properties against DPPH, antimicrobial properties against 3-gram-positive bacterial species, 3-gram negative bacterial species, 3-common bacterial species between aquatic and human, and 3-fungal species, and anticancer properties against breast cancer cells were performed. The results proved that the methanol extract has the highest antimicrobial, antifungal, antioxidant, and anticancer properties. After identifying the compounds of prepared methanol extract using GC/MS, polyvinylpyrrolidone nanofibers containing methanol extract of Daphne mucronata were prepared. The structure and characteristics of prepared nanofibers were confirmed and determined using FTIR, TGA, BET, SEM, flexural strength, compressive strength, and hydrophilicity. Synthesized polyvinylpyrrolidone nanofibers containing methanol extract of D. mucronata were subjected to antimicrobial properties on the strains studied in methanol extract of D. mucronata . The antimicrobial properties of synthesized polyvinylpyrrolidone nanofibers containing methanol extract of D. mucronata were compared. The results showed that synthesized polyvinylpyrrolidone nanofibers containing methanol extract of D. mucronata have the potential to introduction bioactive natural synthesis nanoparticles. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Muzammil, Kzar, Mohammed, Mohammed, Hamood, Hussein, Hanoon, Qasim, Hussien Alawadi and Alsalamy.)
Databáze:	MEDLINE
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