Acquired cystic kidney disease in patients on maintenance hemodialysis, prevalence and associated factors: a cross-sectional study.

Autor: Teuwafeu DG; Department of Internal Medicine and Paediatrics, Faculty of Health Sciences, University of Buea, Buea, Cameroon., Dongmo A; Faculty of Health Sciences, University of Buea, Buea, Cameroon., Fomekong SD; Department of Internal Medicine and Paediatrics, Faculty of Health Sciences, University of Buea, Buea, Cameroon., Amougou M; Department of Clinical Sciences, Faculty of Medicine and Pharmaceutics Sciences, University of Douala, Douala, Cameroon., Mahamat M; Department of Nephrology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon., Nono A; Department of Nephrology, Yaoundé General Hospital, Yaoundé, Cameroon., Kaze FF; Department of Nephrology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon., Ashuntantang G; Department of Nephrology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Jazyk: angličtina
Zdroj: The Pan African medical journal [Pan Afr Med J] 2023 Aug 21; Vol. 45, pp. 175. Date of Electronic Publication: 2023 Aug 21 (Print Publication: 2023).
DOI: 10.11604/pamj.2023.45.175.31773
Abstrakt: Introduction: Acquired Cystic Kidney Disease (ACKD) is a known complication in patients on maintenance hemodialysis, and it is associated with a high risk of malignant transformation. There is a paucity of data on ACKD in sub-Saharan Africa. Objectives: To determine the prevalence and factors associated with acquired cystic kidney disease in patients on maintenance hemodialysis.
Methods: patients on maintenance hemodialysis were screened for ACKD. Patients with hereditary cystic kidney disease were excluded. Renal ultrasounds were performed by two radiologists. ACKD was defined as 3 or more bilateral renal cysts in a small or normal size kidney. Associated factors were determined using logistic regression. A p-value <0.05 was significant.
Results: a total of 158 participants were enrolled and 61.4% (97) were male. Their mean (SD) age was 45.8 (14.9) years. The median dialysis vintage was 33.5 [10.7-63.2] months. The mean (SD) length of the kidneys was 85.1 (17.5) mm on the left and 81.2 (17.1) mm on the right. The prevalence of ACKD was 31.6% (n=50). Septated cysts (4), calcification of the wall of the cysts (2), irregular thick calcified wall (1), septated cysts with calcification (1) and hemorrhagic cyst (1) cysts were also observed. Dialysis vintage > 36 months (OR 7.1, 95% CI: 3.3 - 15.5) and male sex (OR 2.6, 95% CI: 1.2-5.6) were independently associated with ACKD.
Conclusion: the prevalence of ACKD is high in a population of Cameroonians on maintenance. This result calls for the implementation of strategies to screen for the condition and its complications.
Competing Interests: The authors declare no competing interest.
(Copyright: Denis Georges Teuwafeu et al.)
Databáze: MEDLINE
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